A Generative Foundation Model for Chest Radiography
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arXiv
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| Hauptverfasser: | , , , , , , , , , , , , , , |
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| Format: | Preprint |
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2025
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| _version_ | 1866915478654418944 |
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| author | Ji, Yuanfeng Lin, Dan Wang, Xiyue Zhang, Lu Zhou, Wenhui Ge, Chongjian Chu, Ruihang Yang, Xiaoli Zhao, Junhan Chen, Junsong Luo, Xiangde Yang, Sen Fang, Jin Luo, Ping Li, Ruijiang |
| author_facet | Ji, Yuanfeng Lin, Dan Wang, Xiyue Zhang, Lu Zhou, Wenhui Ge, Chongjian Chu, Ruihang Yang, Xiaoli Zhao, Junhan Chen, Junsong Luo, Xiangde Yang, Sen Fang, Jin Luo, Ping Li, Ruijiang |
| contents | The scarcity of well-annotated diverse medical images is a major hurdle for developing reliable AI models in healthcare. Substantial technical advances have been made in generative foundation models for natural images. Here we develop `ChexGen', a generative vision-language foundation model that introduces a unified framework for text-, mask-, and bounding box-guided synthesis of chest radiographs. Built upon the latent diffusion transformer architecture, ChexGen was pretrained on the largest curated chest X-ray dataset to date, consisting of 960,000 radiograph-report pairs. ChexGen achieves accurate synthesis of radiographs through expert evaluations and quantitative metrics. We demonstrate the utility of ChexGen for training data augmentation and supervised pretraining, which led to performance improvements across disease classification, detection, and segmentation tasks using a small fraction of training data. Further, our model enables the creation of diverse patient cohorts that enhance model fairness by detecting and mitigating demographic biases. Our study supports the transformative role of generative foundation models in building more accurate, data-efficient, and equitable medical AI systems. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2509_03903 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | A Generative Foundation Model for Chest Radiography Ji, Yuanfeng Lin, Dan Wang, Xiyue Zhang, Lu Zhou, Wenhui Ge, Chongjian Chu, Ruihang Yang, Xiaoli Zhao, Junhan Chen, Junsong Luo, Xiangde Yang, Sen Fang, Jin Luo, Ping Li, Ruijiang Computer Vision and Pattern Recognition The scarcity of well-annotated diverse medical images is a major hurdle for developing reliable AI models in healthcare. Substantial technical advances have been made in generative foundation models for natural images. Here we develop `ChexGen', a generative vision-language foundation model that introduces a unified framework for text-, mask-, and bounding box-guided synthesis of chest radiographs. Built upon the latent diffusion transformer architecture, ChexGen was pretrained on the largest curated chest X-ray dataset to date, consisting of 960,000 radiograph-report pairs. ChexGen achieves accurate synthesis of radiographs through expert evaluations and quantitative metrics. We demonstrate the utility of ChexGen for training data augmentation and supervised pretraining, which led to performance improvements across disease classification, detection, and segmentation tasks using a small fraction of training data. Further, our model enables the creation of diverse patient cohorts that enhance model fairness by detecting and mitigating demographic biases. Our study supports the transformative role of generative foundation models in building more accurate, data-efficient, and equitable medical AI systems. |
| title | A Generative Foundation Model for Chest Radiography |
| topic | Computer Vision and Pattern Recognition |
| url | https://arxiv.org/abs/2509.03903 |