How many patients could we save with LLM priors?
Fuente:
arXiv
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| Autori principali: | , , , |
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| Natura: | Preprint |
| Pubblicazione: |
2025
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| _version_ | 1866917095069974528 |
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| author | Arai, Shota Selby, David Vargo, Andrew Vollmer, Sebastian |
| author_facet | Arai, Shota Selby, David Vargo, Andrew Vollmer, Sebastian |
| contents | Imagine a world where clinical trials need far fewer patients to achieve the same statistical power, thanks to the knowledge encoded in large language models (LLMs). We present a novel framework for hierarchical Bayesian modeling of adverse events in multi-center clinical trials, leveraging LLM-informed prior distributions. Unlike data augmentation approaches that generate synthetic data points, our methodology directly obtains parametric priors from the model. Our approach systematically elicits informative priors for hyperparameters in hierarchical Bayesian models using a pre-trained LLM, enabling the incorporation of external clinical expertise directly into Bayesian safety modeling. Through comprehensive temperature sensitivity analysis and rigorous cross-validation on real-world clinical trial data, we demonstrate that LLM-derived priors consistently improve predictive performance compared to traditional meta-analytical approaches. This methodology paves the way for more efficient and expert-informed clinical trial design, enabling substantial reductions in the number of patients required to achieve robust safety assessment and with the potential to transform drug safety monitoring and regulatory decision making. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2509_04250 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | How many patients could we save with LLM priors? Arai, Shota Selby, David Vargo, Andrew Vollmer, Sebastian Methodology Artificial Intelligence Emerging Technologies Information Retrieval Applications Imagine a world where clinical trials need far fewer patients to achieve the same statistical power, thanks to the knowledge encoded in large language models (LLMs). We present a novel framework for hierarchical Bayesian modeling of adverse events in multi-center clinical trials, leveraging LLM-informed prior distributions. Unlike data augmentation approaches that generate synthetic data points, our methodology directly obtains parametric priors from the model. Our approach systematically elicits informative priors for hyperparameters in hierarchical Bayesian models using a pre-trained LLM, enabling the incorporation of external clinical expertise directly into Bayesian safety modeling. Through comprehensive temperature sensitivity analysis and rigorous cross-validation on real-world clinical trial data, we demonstrate that LLM-derived priors consistently improve predictive performance compared to traditional meta-analytical approaches. This methodology paves the way for more efficient and expert-informed clinical trial design, enabling substantial reductions in the number of patients required to achieve robust safety assessment and with the potential to transform drug safety monitoring and regulatory decision making. |
| title | How many patients could we save with LLM priors? |
| topic | Methodology Artificial Intelligence Emerging Technologies Information Retrieval Applications |
| url | https://arxiv.org/abs/2509.04250 |