Arrested coarsening, oscillations, and memory from a conserved phase separating nucleator in a self-straining cytoskeletal network
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| Main Authors: | , , , , |
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| Format: | Preprint |
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2025
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| _version_ | 1866911143941898240 |
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| author | Bodini--Lefranc, Quentin Schindelwig, Jakob Weidinger, Daniel Engleder, Lucas Fürthauer, Sebastian |
| author_facet | Bodini--Lefranc, Quentin Schindelwig, Jakob Weidinger, Daniel Engleder, Lucas Fürthauer, Sebastian |
| contents | How do phase separated cellular structures set their size? To elucidate this, we study the dynamics and steady states of a phase separating nucleator that is advected by the self-straining cytoskeletal network which it nucleates. We find (i) that the interplay between transport and the tendency of nucleators to phase separate arrests coarsening; (ii) that the system undergoes damped oscillations towards a patterned steady state with a well defined length scale; (iii) that the system supports a spectrum of patterned states of different steady length scales, enabling the retention of a mechano-chemical memory of the initial conditions. Together, our findings establish a physiologically plausible compound material made of the phase separating nucleator and the self-straining network as a paradigm for mechano-chemical scale selection and memory fixation in cells. |
| format | Preprint |
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arxiv_https___arxiv_org_abs_2509_07181 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | Arrested coarsening, oscillations, and memory from a conserved phase separating nucleator in a self-straining cytoskeletal network Bodini--Lefranc, Quentin Schindelwig, Jakob Weidinger, Daniel Engleder, Lucas Fürthauer, Sebastian Soft Condensed Matter Biological Physics How do phase separated cellular structures set their size? To elucidate this, we study the dynamics and steady states of a phase separating nucleator that is advected by the self-straining cytoskeletal network which it nucleates. We find (i) that the interplay between transport and the tendency of nucleators to phase separate arrests coarsening; (ii) that the system undergoes damped oscillations towards a patterned steady state with a well defined length scale; (iii) that the system supports a spectrum of patterned states of different steady length scales, enabling the retention of a mechano-chemical memory of the initial conditions. Together, our findings establish a physiologically plausible compound material made of the phase separating nucleator and the self-straining network as a paradigm for mechano-chemical scale selection and memory fixation in cells. |
| title | Arrested coarsening, oscillations, and memory from a conserved phase separating nucleator in a self-straining cytoskeletal network |
| topic | Soft Condensed Matter Biological Physics |
| url | https://arxiv.org/abs/2509.07181 |