Mathematical Discovery of Potential Therapeutic Targets: Application to Rare Melanomas
Fuente:
arXiv
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| Autori principali: | , , , , , , , , , , |
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| Natura: | Preprint |
| Pubblicazione: |
2025
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| Soggetti: | |
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| _version_ | 1866910074521255936 |
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| author | Aghaee, Mahya Cicchirillo, Victoria Milner, Rowan Adams, Kyle Bruner, Julia Hager, William Brown, Ashley N. Sayour, Elias Santoro, Domenico Doonan, Bently Moore, Helen |
| author_facet | Aghaee, Mahya Cicchirillo, Victoria Milner, Rowan Adams, Kyle Bruner, Julia Hager, William Brown, Ashley N. Sayour, Elias Santoro, Domenico Doonan, Bently Moore, Helen |
| contents | Patients with rare types of melanoma such as acral, mucosal, or uveal melanoma, have lower survival rates than patients with cutaneous melanoma; these lower survival rates reflect the lower objective response rates to immunotherapy compared to cutaneous melanoma. Understanding tumor-immune dynamics in rare melanomas is critical for the development of new therapies and for improving response rates to current cancer therapies. Progress has been hindered by the lack of clinical data and the need for better preclinical models of rare melanomas. Canine melanoma provides a valuable comparative oncology model for rare types of human melanomas. We analyzed RNA sequencing data from canine melanoma patients and combined this with literature information to create a novel mechanistic mathematical model of melanoma-immune dynamics. Sensitivity analysis of the mathematical model indicated influential pathways in the dynamics, providing support for potential new therapeutic targets and future combinations of therapies. We share our learnings from this work, to help enable the application of this proof-of-concept workflow to other rare disease settings with sparse available data. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2509_08013 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | Mathematical Discovery of Potential Therapeutic Targets: Application to Rare Melanomas Aghaee, Mahya Cicchirillo, Victoria Milner, Rowan Adams, Kyle Bruner, Julia Hager, William Brown, Ashley N. Sayour, Elias Santoro, Domenico Doonan, Bently Moore, Helen Quantitative Methods Patients with rare types of melanoma such as acral, mucosal, or uveal melanoma, have lower survival rates than patients with cutaneous melanoma; these lower survival rates reflect the lower objective response rates to immunotherapy compared to cutaneous melanoma. Understanding tumor-immune dynamics in rare melanomas is critical for the development of new therapies and for improving response rates to current cancer therapies. Progress has been hindered by the lack of clinical data and the need for better preclinical models of rare melanomas. Canine melanoma provides a valuable comparative oncology model for rare types of human melanomas. We analyzed RNA sequencing data from canine melanoma patients and combined this with literature information to create a novel mechanistic mathematical model of melanoma-immune dynamics. Sensitivity analysis of the mathematical model indicated influential pathways in the dynamics, providing support for potential new therapeutic targets and future combinations of therapies. We share our learnings from this work, to help enable the application of this proof-of-concept workflow to other rare disease settings with sparse available data. |
| title | Mathematical Discovery of Potential Therapeutic Targets: Application to Rare Melanomas |
| topic | Quantitative Methods |
| url | https://arxiv.org/abs/2509.08013 |