Molecular-Size Control of Properties of Therapeutic Nano-Paper Allows for Selective Drug Storage in Small Doses
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arXiv
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| Natura: | Preprint |
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2025
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| author | Erbes, Elisabeth Biswas, Naireeta Gavilett, Calvin J. Schwartzkopf, Matthias Basuroy, Krishnayan Chen, Qing Chumakov, Andrei Frenzke, Susann Gensch, Marc Goordeyeva, Korneliya Kielb, Patrycja Kirchner, Sonja Körstgens, Volker Müller-Buschbaum, Peter Müller-Werkmeister, Henrike M. Rubeck, Jan Veedu, Sreevidya Thekku Velazquez-Garcia, Jose de Jesus Waclawek, Vivian Söderberg, Daniel Roth, Stephan V. Techert, Simone |
| author_facet | Erbes, Elisabeth Biswas, Naireeta Gavilett, Calvin J. Schwartzkopf, Matthias Basuroy, Krishnayan Chen, Qing Chumakov, Andrei Frenzke, Susann Gensch, Marc Goordeyeva, Korneliya Kielb, Patrycja Kirchner, Sonja Körstgens, Volker Müller-Buschbaum, Peter Müller-Werkmeister, Henrike M. Rubeck, Jan Veedu, Sreevidya Thekku Velazquez-Garcia, Jose de Jesus Waclawek, Vivian Söderberg, Daniel Roth, Stephan V. Techert, Simone |
| contents | A novel concept of nano-scaled interwoven templates for drug delivery with alternating hydro- and lipophilicity properties is introduced. They are built from cellulose and peptide hydrogel in tandem, and characterized by a nano-stacked interwoven design, thus enabling for tuning the lipophilicity in the mesh nano-domains in which drug candidates of complementary lipophilicities can be embedded. This allows for low-dose-controlled consumption and therapeutic applications. Time-resolved and in-situ grazing incidence X-ray scattering studies confirm the design of the therapeutic nano-paper and create conditions suitable for the drug storage of complementary properties. The molecular design has the potential of a locally controlled, site-specific drug release on a beyond-nanomolar scale. Generalized, the design may contribute to facile developments of personalized medicine. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2509_08019 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | Molecular-Size Control of Properties of Therapeutic Nano-Paper Allows for Selective Drug Storage in Small Doses Erbes, Elisabeth Biswas, Naireeta Gavilett, Calvin J. Schwartzkopf, Matthias Basuroy, Krishnayan Chen, Qing Chumakov, Andrei Frenzke, Susann Gensch, Marc Goordeyeva, Korneliya Kielb, Patrycja Kirchner, Sonja Körstgens, Volker Müller-Buschbaum, Peter Müller-Werkmeister, Henrike M. Rubeck, Jan Veedu, Sreevidya Thekku Velazquez-Garcia, Jose de Jesus Waclawek, Vivian Söderberg, Daniel Roth, Stephan V. Techert, Simone Medical Physics Materials Science Biological Physics A novel concept of nano-scaled interwoven templates for drug delivery with alternating hydro- and lipophilicity properties is introduced. They are built from cellulose and peptide hydrogel in tandem, and characterized by a nano-stacked interwoven design, thus enabling for tuning the lipophilicity in the mesh nano-domains in which drug candidates of complementary lipophilicities can be embedded. This allows for low-dose-controlled consumption and therapeutic applications. Time-resolved and in-situ grazing incidence X-ray scattering studies confirm the design of the therapeutic nano-paper and create conditions suitable for the drug storage of complementary properties. The molecular design has the potential of a locally controlled, site-specific drug release on a beyond-nanomolar scale. Generalized, the design may contribute to facile developments of personalized medicine. |
| title | Molecular-Size Control of Properties of Therapeutic Nano-Paper Allows for Selective Drug Storage in Small Doses |
| topic | Medical Physics Materials Science Biological Physics |
| url | https://arxiv.org/abs/2509.08019 |