An Overview of Physiologically Based Pharmacokinetic (PBPK) and Population Pharmacokinetic (PopPK) Models
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arXiv
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| Main Authors: | , , , , , |
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| Format: | Preprint |
| Published: |
2025
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| _version_ | 1866914117468553216 |
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| author | Hardiansyah, Deni Patrianesha, Bisma Baron Shi, Kuangyu Saboury, Babak Rahmim, Arman Glatting, Gerhard |
| author_facet | Hardiansyah, Deni Patrianesha, Bisma Baron Shi, Kuangyu Saboury, Babak Rahmim, Arman Glatting, Gerhard |
| contents | This review discusses the current applications, advantages, and limitations of PBPK and PopPK models in radiopharmaceutical therapy (RPT). PBPK models simulate radiopharmaceutical kinetics by integrating prior physiological and drug parameter information, whereas PopPK models leverage population data to enhance individual dose estimation accuracy. Future directions include developing hybrid models, incorporating artificial intelligence, and establishing regulatory guidelines to promote their clinical adoption. Ultimately, these modeling strategies aim to enable precise, personalized RPT dosing, thereby improving therapeutic outcomes and safety. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2509_09755 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | An Overview of Physiologically Based Pharmacokinetic (PBPK) and Population Pharmacokinetic (PopPK) Models Hardiansyah, Deni Patrianesha, Bisma Baron Shi, Kuangyu Saboury, Babak Rahmim, Arman Glatting, Gerhard Medical Physics Applied Physics This review discusses the current applications, advantages, and limitations of PBPK and PopPK models in radiopharmaceutical therapy (RPT). PBPK models simulate radiopharmaceutical kinetics by integrating prior physiological and drug parameter information, whereas PopPK models leverage population data to enhance individual dose estimation accuracy. Future directions include developing hybrid models, incorporating artificial intelligence, and establishing regulatory guidelines to promote their clinical adoption. Ultimately, these modeling strategies aim to enable precise, personalized RPT dosing, thereby improving therapeutic outcomes and safety. |
| title | An Overview of Physiologically Based Pharmacokinetic (PBPK) and Population Pharmacokinetic (PopPK) Models |
| topic | Medical Physics Applied Physics |
| url | https://arxiv.org/abs/2509.09755 |