FireGNN: Neuro-Symbolic Graph Neural Networks with Trainable Fuzzy Rules for Interpretable Medical Image Classification

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Auteurs principaux: Sengupta, Prajit, Rekik, Islem
Format: Preprint
Publié: 2025
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author Sengupta, Prajit
Rekik, Islem
author_facet Sengupta, Prajit
Rekik, Islem
contents Medical image classification requires not only high predictive performance but also interpretability to ensure clinical trust and adoption. Graph Neural Networks (GNNs) offer a powerful framework for modeling relational structures within datasets; however, standard GNNs often operate as black boxes, limiting transparency and usability, particularly in clinical settings. In this work, we present an interpretable graph-based learning framework named FireGNN that integrates trainable fuzzy rules into GNNs for medical image classification. These rules embed topological descriptors - node degree, clustering coefficient, and label agreement - using learnable thresholds and sharpness parameters to enable intrinsic symbolic reasoning. Additionally, we explore auxiliary self-supervised tasks (e.g., homophily prediction, similarity entropy) as a benchmark to evaluate the contribution of topological learning. Our fuzzy-rule-enhanced model achieves strong performance across five MedMNIST benchmarks and the synthetic dataset MorphoMNIST, while also generating interpretable rule-based explanations. To our knowledge, this is the first integration of trainable fuzzy rules within a GNN. Source Code: https://github.com/basiralab/FireGNN
format Preprint
id arxiv_https___arxiv_org_abs_2509_10510
institution arXiv
publishDate 2025
record_format arxiv
spellingShingle FireGNN: Neuro-Symbolic Graph Neural Networks with Trainable Fuzzy Rules for Interpretable Medical Image Classification
Sengupta, Prajit
Rekik, Islem
Image and Video Processing
Artificial Intelligence
Computer Vision and Pattern Recognition
Machine Learning
Medical image classification requires not only high predictive performance but also interpretability to ensure clinical trust and adoption. Graph Neural Networks (GNNs) offer a powerful framework for modeling relational structures within datasets; however, standard GNNs often operate as black boxes, limiting transparency and usability, particularly in clinical settings. In this work, we present an interpretable graph-based learning framework named FireGNN that integrates trainable fuzzy rules into GNNs for medical image classification. These rules embed topological descriptors - node degree, clustering coefficient, and label agreement - using learnable thresholds and sharpness parameters to enable intrinsic symbolic reasoning. Additionally, we explore auxiliary self-supervised tasks (e.g., homophily prediction, similarity entropy) as a benchmark to evaluate the contribution of topological learning. Our fuzzy-rule-enhanced model achieves strong performance across five MedMNIST benchmarks and the synthetic dataset MorphoMNIST, while also generating interpretable rule-based explanations. To our knowledge, this is the first integration of trainable fuzzy rules within a GNN. Source Code: https://github.com/basiralab/FireGNN
title FireGNN: Neuro-Symbolic Graph Neural Networks with Trainable Fuzzy Rules for Interpretable Medical Image Classification
topic Image and Video Processing
Artificial Intelligence
Computer Vision and Pattern Recognition
Machine Learning
url https://arxiv.org/abs/2509.10510