Imagen de Portada

BE-BOIN: A Dose Optimization Design Accommodating Backfill and Late-Onset Toxicity

Fuente: arXiv

Guardado en:

Detalles Bibliográficos
Autores principales:	Chen, Kai, Zhao, Yixuan, Takeda, Kentaro, Yuan, Ying
Formato:	Preprint
Publicado:	2025
Materias:	Methodology
Acceso en línea:	Acceder al recurso
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares

ROMI: A Randomized Two-Stage Basket Trial Design to Optimize Doses for Multiple Indications
por: Wang, Shuqi, et al.
Publicado: (2024)

BOIN Designs for Dose Escalation With Selected Dose Combinations in Oncology Phase I Trials
por: Chen, Yuxuan, et al.
Publicado: (2026)

BOP2-TE: Bayesian Optimal Phase 2 Design for Jointly Monitoring Efficacy and Toxicity with Application to Dose Optimization
por: Chen, Kai, et al.
Publicado: (2024)

Dual-criterion Dose Finding Designs Based on Dose-Limiting Toxicity and Tolerability
por: Yang, Yunlong, et al.
Publicado: (2024)

ROSE: Randomized Optimal Selection Design for Dose Optimization
por: Wang, Shuqi, et al.
Publicado: (2025)

Hybrid Non-informative and Informative Prior Model-assisted Designs for Mid-trial Dose Insertion
por: Yamada, Kana, et al.
Publicado: (2026)

BOIN ‐ MEM : A Two‐Stage Design for Dose Optimization With Information Borrowing Across Dose Levels and Stages in Oncology Phase I/ II Trials
por: Ryo Kitabayashi, et al.
Publicado: (2025)

COMIC: A Bayesian Dose Optimization Design for Drug Combination in Multiple Indications With Application to CAR‐T Therapies
por: Kai Chen, et al.
Publicado: (2025)

Utility-Based Dose Optimization Approaches for Multiple-Dose Randomized Trial Designs Accounting for Multiple Endpoints
por: DAngelo, Gina, et al.
Publicado: (2025)

Should the choice of BOIN design parameter p.tox only depend on the target DLT rate?
por: Lu, Rong
Publicado: (2024)

Statistical Operating Characteristics of Current Early Phase Dose Finding Designs with Toxicity and Efficacy in Oncology
por: Sun, Hao, et al.
Publicado: (2024)

BARD: A seamless two-stage dose optimization design integrating backfill and adaptive randomization
por: Zhao, Yixuan, et al.
Publicado: (2024)

Modifying Survival Models To Accommodate Thresholding Behavior
por: Betancourt, Michael
Publicado: (2022)

A Seamless Phase II/III Design with Dose Optimization for Oncology Drug Development
por: Li, Yuhan, et al.
Publicado: (2024)

Precision Dose-Finding Design for Phase I Oncology Trials by Integrating Pharmacology Data
por: Lee, Kyong Ju, et al.
Publicado: (2025)

Bayesian Optimization for Identification of Optimal Biological Dose Combinations in Personalized Dose-Finding Trials
por: Willard, James, et al.
Publicado: (2024)

A Likelihood Perspective on Dose-Finding Study Designs in Oncology
por: Zhang, Zhiwei
Publicado: (2023)

Two-dose vs. Three-Dose Optimization Under Sample Size Constraint
por: Sun, Linda, et al.
Publicado: (2026)

TWICEBEE: A Two-stage Intra-patient Curve-free Bayesian Decision-Theoretic Dose Escalation Design
por: Bi, Dehua, et al.
Publicado: (2026)

Prior-Free Sample Size Design for Test-and-Roll Experiments
por: Kawato, Kentaro, et al.
Publicado: (2026)

A Utility Score Framework for Dose Optimization Studies with Binary Efficacy-Safety Endpoints: Sample Size Determination and Bias Characterization
por: Gu, Xuemin, et al.
Publicado: (2026)

Scale-Location-Truncated Beta Regression: Expanding Beta Regression to Accommodate 0 and 1
por: Kim, Mingang, et al.
Publicado: (2025)

Bayesian Optimization for Personalized Dose-Finding Trials with Combination Therapies
por: Willard, James, et al.
Publicado: (2023)

Reclustering: A New Method to Test the Appropriate Level of Clustering
por: Fukumoto, Kentaro
Publicado: (2025)

sfislands: An R Package for Accommodating Islands and Disjoint Zones in Areal Spatial Modelling
por: Horan, Kevin, et al.
Publicado: (2024)

Personalized Two-sided Dose Interval
por: Park, Chan, et al.
Publicado: (2023)

An Adaptive Phase II Trial Design for Dose Selection and Addition in Microfilarial Infections
por: Zehetmayer, Sonja, et al.
Publicado: (2026)

CUI-MET: Clinical Utility Index Dose Optimization Approach for Multiple-Dose, Multiple-Outcome Randomized Trial Designs
por: Zhang, Fanni, et al.
Publicado: (2025)

LORDs: Locally Optimal Restricted Designs for Phase I/II Dose-Finding Studies
por: Sverdlov, Oleksandr, et al.
Publicado: (2025)

Accommodating informative visit times for analysing irregular longitudinal data: a sensitivity analysis approach with balancing weights estimators
por: Yiu, Sean, et al.
Publicado: (2023)

Experimental Design For Causal Inference Through An Optimization Lens
por: Zhao, Jinglong
Publicado: (2024)

Balancing Weights for Causal Mediation Analysis
por: Kawato, Kentaro
Publicado: (2025)

TITE-STEIN: Time-to-event Simple Toxicity and Efficacy Interval Design to Accelerate Phase I/II Trials
por: Sun, Hao, et al.
Publicado: (2025)

Bridging the Gap Between Design and Analysis: Randomization Inference and Sensitivity Analysis for Matched Observational Studies with Treatment Doses
por: Zhang, Jeffrey, et al.
Publicado: (2024)

DEMO: Dose Exploration, Monitoring, and Optimization Using a Biological Mediator for Clinical Outcomes
por: Yang, Cheng-Han, et al.
Publicado: (2024)

Estimands for Early Phase Dose Optimization Trials in Oncology
por: Mukherjee, Ayon, et al.
Publicado: (2025)

Evaluating Bias Reduction Methods in Binary Emax Model for Reliable Dose-Response Estimation
por: Zhang, Jiangshan, et al.
Publicado: (2025)

The Backfill i3+3 Design for Dose-Finding Trials in Oncology
por: Liu, Jiaxin, et al.
Publicado: (2023)

Robust Emax Model Fitting: Addressing Nonignorable Missing Binary Outcome in Dose-Response Analysis
por: Zhang, Jiangshan, et al.
Publicado: (2024)

Dempster-Shafer P-values: Thoughts on an Alternative Approach for Multinomial Inference
por: Hoffman, Kentaro, et al.
Publicado: (2024)