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| Natura: | Preprint |
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2025
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| Accesso online: | https://arxiv.org/abs/2509.12666 |
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| _version_ | 1866908848070066176 |
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| author | Wickramasinghe, Charuka D. Weerasinghe, Krishanthi C. Ranaweera, Pradeep K. Hapuhinna, Nelum S. S. M. |
| author_facet | Wickramasinghe, Charuka D. Weerasinghe, Krishanthi C. Ranaweera, Pradeep K. Hapuhinna, Nelum S. S. M. |
| contents | Physics-Informed Neural Networks (PINNs) integrate machine learning with differential equations to solve forward and inverse problems while ensuring that predictions adhere to physical laws. Physiologically based pharmacokinetic (PBPK) modeling advances beyond classical compartmental approaches by employing a mechanistic, physiology-focused framework. Such models involve many unknown parameters that are difficult to measure directly in humans due to ethical and practical constraints. PBPK models are constructed as systems of ordinary differential equations (ODEs) and these parametric ODEs are often stiff, and traditional numerical and statistical methods frequently fail to converge. In this study, we consider a permeability-limited, four-compartment PBPK brain model that mimics human brain functionality in drug delivery. We introduce PBPK-iPINN, a method for estimating drug-specific or patient-specific parameters and drug concentration profiles using inverse PINNs. We also conducted parameter identifiability analysis to determines whether the parameters can be uniquely and reliably estimated from the available data. We demonstrate that, for the inverse problem to converge to the correct solution, the components of the loss function (data loss, initial condition loss, and residual loss) must be appropriately weighted, and the hyperparameters including the number of layers and neurons, activation functions, learning rate, optimizer, and collocation points must be carefully tuned. The performance of the PBPK-iPINN approach is then compared with established numerical and statistical methods. Accurate parameter estimation yields precise drug concentration-time profiles, which in turn enable the calculation of pharmacokinetic metrics. These metrics support drug developers and clinicians in designing and optimizing therapies for brain cancer. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2509_12666 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | PBPK-iPINNs: Inverse Physics-Informed Neural Networks for Physiologically Based Pharmacokinetic Brain Models Wickramasinghe, Charuka D. Weerasinghe, Krishanthi C. Ranaweera, Pradeep K. Hapuhinna, Nelum S. S. M. Machine Learning Numerical Analysis 65L04, 65L09, 92B20 Physics-Informed Neural Networks (PINNs) integrate machine learning with differential equations to solve forward and inverse problems while ensuring that predictions adhere to physical laws. Physiologically based pharmacokinetic (PBPK) modeling advances beyond classical compartmental approaches by employing a mechanistic, physiology-focused framework. Such models involve many unknown parameters that are difficult to measure directly in humans due to ethical and practical constraints. PBPK models are constructed as systems of ordinary differential equations (ODEs) and these parametric ODEs are often stiff, and traditional numerical and statistical methods frequently fail to converge. In this study, we consider a permeability-limited, four-compartment PBPK brain model that mimics human brain functionality in drug delivery. We introduce PBPK-iPINN, a method for estimating drug-specific or patient-specific parameters and drug concentration profiles using inverse PINNs. We also conducted parameter identifiability analysis to determines whether the parameters can be uniquely and reliably estimated from the available data. We demonstrate that, for the inverse problem to converge to the correct solution, the components of the loss function (data loss, initial condition loss, and residual loss) must be appropriately weighted, and the hyperparameters including the number of layers and neurons, activation functions, learning rate, optimizer, and collocation points must be carefully tuned. The performance of the PBPK-iPINN approach is then compared with established numerical and statistical methods. Accurate parameter estimation yields precise drug concentration-time profiles, which in turn enable the calculation of pharmacokinetic metrics. These metrics support drug developers and clinicians in designing and optimizing therapies for brain cancer. |
| title | PBPK-iPINNs: Inverse Physics-Informed Neural Networks for Physiologically Based Pharmacokinetic Brain Models |
| topic | Machine Learning Numerical Analysis 65L04, 65L09, 92B20 |
| url | https://arxiv.org/abs/2509.12666 |