Emergent complexity and rhythms in evoked and spontaneous dynamics of human whole-brain models after tuning through analysis tools
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2025
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| author | Gaglioti, Gianluca Cardinale, Alessandra Lupo, Cosimo Nieus, Thierry Marmoreo, Federico Focacci, Elena Gutzen, Robin Denker, Michael Pigorini, Andrea Massimini, Marcello Sarasso, Simone Paolucci, Pier Stanislao De Bonis, Giulia |
| author_facet | Gaglioti, Gianluca Cardinale, Alessandra Lupo, Cosimo Nieus, Thierry Marmoreo, Federico Focacci, Elena Gutzen, Robin Denker, Michael Pigorini, Andrea Massimini, Marcello Sarasso, Simone Paolucci, Pier Stanislao De Bonis, Giulia |
| contents | The simulation of whole-brain dynamics should reproduce realistic spontaneous and evoked neural activity across different scales, including emergent rhythms, spatio-temporal activation patterns, and macroscale complexity. Once a mathematical model is selected, its configuration must be determined by properly setting its parameters. A critical preliminary step in this process is defining an appropriate set of observables to guide the selection of model configurations (parameter tuning), laying the groundwork for quantitative calibration of accurate whole-brain models. Here, we address this challenge by presenting a framework that integrates two complementary tools: The Virtual Brain (TVB) platform for simulating whole-brain dynamics, and the Collaborative Brain Wave Analysis Pipeline (Cobrawap) for analyzing simulation outputs using a set of standardized metrics. We apply this framework to a 998-node human connectome, using two configurations of the Larter-Breakspear neural mass model: one with the TVB default parameters, the other tuned using Cobrawap. The results reveal that the tuned configuration exhibits several biologically relevant features, absent in the default model for both spontaneous and evoked dynamics. In response to external perturbations, the tuned model generates non-stereotyped, complex spatio-temporal activity, as measured by the perturbational complexity index. In spontaneous activity, it exhibits robust alpha-band oscillations, infra-slow rhythms, scale-free characteristics, greater spatio-temporal heterogeneity, and asymmetric functional connectivity. This work demonstrates how combining TVB and Cobrawap can guide parameter tuning and lays the groundwork for data-driven calibration and validation of accurate whole-brain models. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2509_12873 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | Emergent complexity and rhythms in evoked and spontaneous dynamics of human whole-brain models after tuning through analysis tools Gaglioti, Gianluca Cardinale, Alessandra Lupo, Cosimo Nieus, Thierry Marmoreo, Federico Focacci, Elena Gutzen, Robin Denker, Michael Pigorini, Andrea Massimini, Marcello Sarasso, Simone Paolucci, Pier Stanislao De Bonis, Giulia Neurons and Cognition Distributed, Parallel, and Cluster Computing Computational Physics The simulation of whole-brain dynamics should reproduce realistic spontaneous and evoked neural activity across different scales, including emergent rhythms, spatio-temporal activation patterns, and macroscale complexity. Once a mathematical model is selected, its configuration must be determined by properly setting its parameters. A critical preliminary step in this process is defining an appropriate set of observables to guide the selection of model configurations (parameter tuning), laying the groundwork for quantitative calibration of accurate whole-brain models. Here, we address this challenge by presenting a framework that integrates two complementary tools: The Virtual Brain (TVB) platform for simulating whole-brain dynamics, and the Collaborative Brain Wave Analysis Pipeline (Cobrawap) for analyzing simulation outputs using a set of standardized metrics. We apply this framework to a 998-node human connectome, using two configurations of the Larter-Breakspear neural mass model: one with the TVB default parameters, the other tuned using Cobrawap. The results reveal that the tuned configuration exhibits several biologically relevant features, absent in the default model for both spontaneous and evoked dynamics. In response to external perturbations, the tuned model generates non-stereotyped, complex spatio-temporal activity, as measured by the perturbational complexity index. In spontaneous activity, it exhibits robust alpha-band oscillations, infra-slow rhythms, scale-free characteristics, greater spatio-temporal heterogeneity, and asymmetric functional connectivity. This work demonstrates how combining TVB and Cobrawap can guide parameter tuning and lays the groundwork for data-driven calibration and validation of accurate whole-brain models. |
| title | Emergent complexity and rhythms in evoked and spontaneous dynamics of human whole-brain models after tuning through analysis tools |
| topic | Neurons and Cognition Distributed, Parallel, and Cluster Computing Computational Physics |
| url | https://arxiv.org/abs/2509.12873 |