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| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Preprint |
| Published: |
2025
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| Subjects: | |
| Online Access: | https://arxiv.org/abs/2509.14972 |
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| _version_ | 1866912592621993984 |
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| author | Gerwert, Grischa Mann, Marvin Langenhoff, Lennart Woitzik, Nathalie Hubert, Diana Duman, Deniz Hoeveler, Adrian Budde, Sandy Simon, Jonas Beyer, Leon Schuler, Martin Weber, Sandrina Mollenhauer, Brit Kötting, Carsten Gueldenhaupt, Joern Gerwert, Klaus |
| author_facet | Gerwert, Grischa Mann, Marvin Langenhoff, Lennart Woitzik, Nathalie Hubert, Diana Duman, Deniz Hoeveler, Adrian Budde, Sandy Simon, Jonas Beyer, Leon Schuler, Martin Weber, Sandrina Mollenhauer, Brit Kötting, Carsten Gueldenhaupt, Joern Gerwert, Klaus |
| contents | The immuno-infrared sensor detects target proteins in solution. Exemplary, the initial misfolding of amyloid beta (Abeta) peptides in blood is measured, enabling early risk prediction of Alzheimer's disease in the preclinical stage. Antibodies concentrate the target protein on the functionalized attenuated total reflection crystal surface. A quantum cascade laser is used to measure the amide I band, which indicates the secondary structure distribution of Abeta in blood as a biomarker. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2509_14972 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | An immuno-Infrared Sensor detects preclinical Alzheimer's and Parkinson's Disease by misfolding Gerwert, Grischa Mann, Marvin Langenhoff, Lennart Woitzik, Nathalie Hubert, Diana Duman, Deniz Hoeveler, Adrian Budde, Sandy Simon, Jonas Beyer, Leon Schuler, Martin Weber, Sandrina Mollenhauer, Brit Kötting, Carsten Gueldenhaupt, Joern Gerwert, Klaus Biological Physics The immuno-infrared sensor detects target proteins in solution. Exemplary, the initial misfolding of amyloid beta (Abeta) peptides in blood is measured, enabling early risk prediction of Alzheimer's disease in the preclinical stage. Antibodies concentrate the target protein on the functionalized attenuated total reflection crystal surface. A quantum cascade laser is used to measure the amide I band, which indicates the secondary structure distribution of Abeta in blood as a biomarker. |
| title | An immuno-Infrared Sensor detects preclinical Alzheimer's and Parkinson's Disease by misfolding |
| topic | Biological Physics |
| url | https://arxiv.org/abs/2509.14972 |