A self-organized compression network arrests epithelial proliferation
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arXiv
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| Main Authors: | , , , , , |
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| Format: | Preprint |
| Published: |
2025
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| _version_ | 1866909959046823936 |
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| author | Daraf, Liav Lavi, Yael Saleem, Areej Sanchez, Daniel Sevilla Feldman, Yuri Atia, Lior |
| author_facet | Daraf, Liav Lavi, Yael Saleem, Areej Sanchez, Daniel Sevilla Feldman, Yuri Atia, Lior |
| contents | As epithelial development or wound closure approaches completion, cell proliferation progressively slows via contact inhibition of proliferation (CIP) - a mechanism understood as being strictly local. Here we report the discovery of inhibition of proliferation through an unanticipated mechanism that is non-local. As a confluent epithelial layer becomes progressively more jammed, two interpenetrating networks emerge: islands of mechanically compressed non-cycling cells percolating within an ocean of mechanically tensed cycling cells. The evolution of the compression network was found to be susceptible to both specific molecular stimulus and to injury-induced unjamming. Yet, in all circumstances, the size of compressed islands followed a power-law distribution that was well-captured by preferential network theory. Together, these findings demonstrate the existence of a network-based inhibition of proliferation (NIP) that is self-organizing and poised in proximity to criticality. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2509_16661 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | A self-organized compression network arrests epithelial proliferation Daraf, Liav Lavi, Yael Saleem, Areej Sanchez, Daniel Sevilla Feldman, Yuri Atia, Lior Cell Behavior Soft Condensed Matter Adaptation and Self-Organizing Systems Biological Physics Tissues and Organs As epithelial development or wound closure approaches completion, cell proliferation progressively slows via contact inhibition of proliferation (CIP) - a mechanism understood as being strictly local. Here we report the discovery of inhibition of proliferation through an unanticipated mechanism that is non-local. As a confluent epithelial layer becomes progressively more jammed, two interpenetrating networks emerge: islands of mechanically compressed non-cycling cells percolating within an ocean of mechanically tensed cycling cells. The evolution of the compression network was found to be susceptible to both specific molecular stimulus and to injury-induced unjamming. Yet, in all circumstances, the size of compressed islands followed a power-law distribution that was well-captured by preferential network theory. Together, these findings demonstrate the existence of a network-based inhibition of proliferation (NIP) that is self-organizing and poised in proximity to criticality. |
| title | A self-organized compression network arrests epithelial proliferation |
| topic | Cell Behavior Soft Condensed Matter Adaptation and Self-Organizing Systems Biological Physics Tissues and Organs |
| url | https://arxiv.org/abs/2509.16661 |