Cooperative Function with Thermal Fluctuations in Mechanical Networks
Fuente:
arXiv
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| Autori principali: | , , , |
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| Natura: | Preprint |
| Pubblicazione: |
2025
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| Soggetti: | |
| Accesso online: | |
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| _version_ | 1866916968180744192 |
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| author | Pisanty, Ben Andrejevic, Jovana Liu, Andrea J. Nagel, Sidney R. |
| author_facet | Pisanty, Ben Andrejevic, Jovana Liu, Andrea J. Nagel, Sidney R. |
| contents | Elastic networks can be tuned to exhibit complex mechanical responses and have been extensively used to study protein allosteric functionality, where a localized strain regulates the conformation at a distant site. We show that cooperative binding, where two sites each enhance the other's ability to function, can be trained via a symmetric application of the training previously employed for creating network allostery. We identify a crossover temperature above which cooperative functionality breaks down due to thermal fluctuations. We develop a modified training protocol to increase this crossover temperature, enabling function to remain robust at biologically relevant temperatures. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2509_20560 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | Cooperative Function with Thermal Fluctuations in Mechanical Networks Pisanty, Ben Andrejevic, Jovana Liu, Andrea J. Nagel, Sidney R. Soft Condensed Matter Elastic networks can be tuned to exhibit complex mechanical responses and have been extensively used to study protein allosteric functionality, where a localized strain regulates the conformation at a distant site. We show that cooperative binding, where two sites each enhance the other's ability to function, can be trained via a symmetric application of the training previously employed for creating network allostery. We identify a crossover temperature above which cooperative functionality breaks down due to thermal fluctuations. We develop a modified training protocol to increase this crossover temperature, enabling function to remain robust at biologically relevant temperatures. |
| title | Cooperative Function with Thermal Fluctuations in Mechanical Networks |
| topic | Soft Condensed Matter |
| url | https://arxiv.org/abs/2509.20560 |