Dynamic transitions for fast joint acquisition and reconstruction of CEST-Rex and T1
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| Main Authors: | , , , , , , |
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| Format: | Preprint |
| Published: |
2025
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| _version_ | 1866917365181054976 |
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| author | Huemer, Markus Stilianu, Clemens Scholand, Nick Mackner, Daniel Uecker, Martin Zaiss, Moritz Stollberger, and Rudolf |
| author_facet | Huemer, Markus Stilianu, Clemens Scholand, Nick Mackner, Daniel Uecker, Martin Zaiss, Moritz Stollberger, and Rudolf |
| contents | Purpose: This work proposes a method for the simultaneous estimation of the exchange-dependent relaxation rate Rex and the longitudinal relaxation time T1 from a single acquisition. Methods: A novel acquisition scheme was developed that combines CEST saturation with an inversion pulse and a Look-Locker readout to capture the magnetization evolution starting from the inverse transient Z-spectrum. The corresponding signal model, derived from the Bloch-McConnell equations, describes both the transient Z-spectrum and the Look-Locker dynamics. A model-based reconstruction approach is employed to jointly estimate Rex and T1. The proposed method was validated using a numerical phantom and benchmarked against conventional CEST and Look-Locker T1 mapping in phantom and in vivo on a clinical 3T scanner. Results: The joint estimation approach demonstrated strong agreement with ground truth and conventional methods across a wide range of T1 and CEST parameters. The acquisition time was reduced by 20-30% compared to standard CEST protocols, while providing higher signal-to-noise ratio (SNR) in parameter maps. Conclusion: The proposed technique enables robust and efficient simultaneous quantification of CEST Rex and T1 in a single acquisition. It improves parameter map quality and reduces scan time, making it suitable for both phantom and in vivo imaging across a wide range of physiological conditions. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2509_21184 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | Dynamic transitions for fast joint acquisition and reconstruction of CEST-Rex and T1 Huemer, Markus Stilianu, Clemens Scholand, Nick Mackner, Daniel Uecker, Martin Zaiss, Moritz Stollberger, and Rudolf Medical Physics Purpose: This work proposes a method for the simultaneous estimation of the exchange-dependent relaxation rate Rex and the longitudinal relaxation time T1 from a single acquisition. Methods: A novel acquisition scheme was developed that combines CEST saturation with an inversion pulse and a Look-Locker readout to capture the magnetization evolution starting from the inverse transient Z-spectrum. The corresponding signal model, derived from the Bloch-McConnell equations, describes both the transient Z-spectrum and the Look-Locker dynamics. A model-based reconstruction approach is employed to jointly estimate Rex and T1. The proposed method was validated using a numerical phantom and benchmarked against conventional CEST and Look-Locker T1 mapping in phantom and in vivo on a clinical 3T scanner. Results: The joint estimation approach demonstrated strong agreement with ground truth and conventional methods across a wide range of T1 and CEST parameters. The acquisition time was reduced by 20-30% compared to standard CEST protocols, while providing higher signal-to-noise ratio (SNR) in parameter maps. Conclusion: The proposed technique enables robust and efficient simultaneous quantification of CEST Rex and T1 in a single acquisition. It improves parameter map quality and reduces scan time, making it suitable for both phantom and in vivo imaging across a wide range of physiological conditions. |
| title | Dynamic transitions for fast joint acquisition and reconstruction of CEST-Rex and T1 |
| topic | Medical Physics |
| url | https://arxiv.org/abs/2509.21184 |