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Main Authors: Zhao, Ruixuan, Hua, Xuanwen, Baek, Woongjae, Wang, Zhaoqiang, Jia, Shu, Gao, Liang
Format: Preprint
Published: 2025
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Online Access:https://arxiv.org/abs/2509.24191
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author Zhao, Ruixuan
Hua, Xuanwen
Baek, Woongjae
Wang, Zhaoqiang
Jia, Shu
Gao, Liang
author_facet Zhao, Ruixuan
Hua, Xuanwen
Baek, Woongjae
Wang, Zhaoqiang
Jia, Shu
Gao, Liang
contents Light-field imaging is an emerging paradigm in biomedical optics, offering the unique ability to capture volumetric information in a single snapshot by encoding both the spatial and angular components of light. Unlike conventional three-dimensional (3D) imaging modalities that rely on mechanical or optical scanning, light-field imaging enables high-speed volumetric acquisition, making it particularly well-suited for capturing rapid biological dynamics. This review outlines the theoretical foundations of light-field imaging and surveys its core implementations across microscopy, mesoscopy, and endoscopy. Special attention is given to the fundamental trade-offs between imaging speed, spatial resolution, and depth of field, as well as recent advances that address these limitations through compressive sensing, deep learning, and meta-optics. By positioning light-field imaging within the broader landscape of biomedical imaging technologies, we highlight its unique strengths, existing challenges, and future potential as a scalable and versatile tool for biological discovery and clinical applications.
format Preprint
id arxiv_https___arxiv_org_abs_2509_24191
institution arXiv
publishDate 2025
record_format arxiv
spellingShingle A Review of Light-Field Imaging in Biomedical Sciences
Zhao, Ruixuan
Hua, Xuanwen
Baek, Woongjae
Wang, Zhaoqiang
Jia, Shu
Gao, Liang
Optics
Computational Physics
Light-field imaging is an emerging paradigm in biomedical optics, offering the unique ability to capture volumetric information in a single snapshot by encoding both the spatial and angular components of light. Unlike conventional three-dimensional (3D) imaging modalities that rely on mechanical or optical scanning, light-field imaging enables high-speed volumetric acquisition, making it particularly well-suited for capturing rapid biological dynamics. This review outlines the theoretical foundations of light-field imaging and surveys its core implementations across microscopy, mesoscopy, and endoscopy. Special attention is given to the fundamental trade-offs between imaging speed, spatial resolution, and depth of field, as well as recent advances that address these limitations through compressive sensing, deep learning, and meta-optics. By positioning light-field imaging within the broader landscape of biomedical imaging technologies, we highlight its unique strengths, existing challenges, and future potential as a scalable and versatile tool for biological discovery and clinical applications.
title A Review of Light-Field Imaging in Biomedical Sciences
topic Optics
Computational Physics
url https://arxiv.org/abs/2509.24191