Translation from Wearable PPG to 12-Lead ECG

Fuente: arXiv
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Main Authors: Ji, Hui, Gao, Wei, Zhou, Pengfei
Format: Preprint
Published: 2025
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author Ji, Hui
Gao, Wei
Zhou, Pengfei
author_facet Ji, Hui
Gao, Wei
Zhou, Pengfei
contents The 12-lead electrocardiogram (ECG) is the gold standard for cardiovascular monitoring, offering superior diagnostic granularity and specificity compared to photoplethysmography (PPG). However, existing 12-lead ECG systems rely on cumbersome multi-electrode setups, limiting sustained monitoring in ambulatory settings, while current PPG-based methods fail to reconstruct multi-lead ECG due to the absence of inter-lead constraints and insufficient modeling of spatial-temporal dependencies across leads. To bridge this gap, we introduce P2Es, an innovative demographic-aware diffusion framework designed to generate clinically valid 12-lead ECG from PPG signals via three key innovations. Specifically, in the forward process, we introduce frequency-domain blurring followed by temporal noise interference to simulate real-world signal distortions. In the reverse process, we design a temporal multi-scale generation module followed by frequency deblurring. In particular, we leverage KNN-based clustering combined with contrastive learning to assign affinity matrices for the reverse process, enabling demographic-specific ECG translation. Extensive experimental results show that P2Es outperforms baseline models in 12-lead ECG reconstruction.
format Preprint
id arxiv_https___arxiv_org_abs_2509_25480
institution arXiv
publishDate 2025
record_format arxiv
spellingShingle Translation from Wearable PPG to 12-Lead ECG
Ji, Hui
Gao, Wei
Zhou, Pengfei
Machine Learning
Artificial Intelligence
The 12-lead electrocardiogram (ECG) is the gold standard for cardiovascular monitoring, offering superior diagnostic granularity and specificity compared to photoplethysmography (PPG). However, existing 12-lead ECG systems rely on cumbersome multi-electrode setups, limiting sustained monitoring in ambulatory settings, while current PPG-based methods fail to reconstruct multi-lead ECG due to the absence of inter-lead constraints and insufficient modeling of spatial-temporal dependencies across leads. To bridge this gap, we introduce P2Es, an innovative demographic-aware diffusion framework designed to generate clinically valid 12-lead ECG from PPG signals via three key innovations. Specifically, in the forward process, we introduce frequency-domain blurring followed by temporal noise interference to simulate real-world signal distortions. In the reverse process, we design a temporal multi-scale generation module followed by frequency deblurring. In particular, we leverage KNN-based clustering combined with contrastive learning to assign affinity matrices for the reverse process, enabling demographic-specific ECG translation. Extensive experimental results show that P2Es outperforms baseline models in 12-lead ECG reconstruction.
title Translation from Wearable PPG to 12-Lead ECG
topic Machine Learning
Artificial Intelligence
url https://arxiv.org/abs/2509.25480