An infection-responsive collagen-based wet-spun textile fibre for wound monitoring
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arXiv
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| Auteurs principaux: | , , , |
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| Format: | Preprint |
| Publié: |
2025
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| _version_ | 1866916981508145152 |
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| author | Gorman, Jonathon Brooker, Charles Li, Xinyu Tronci, Giuseppe |
| author_facet | Gorman, Jonathon Brooker, Charles Li, Xinyu Tronci, Giuseppe |
| contents | Wound infections are a significant clinical and socioeconomic challenge, contributing to delayed healing and increased wound chronicity. To enable early infection detection and inform therapeutic decisions, this study investigated the design of pH-responsive collagen fibres using a scalable wet spinning process, evaluating product suitability for textile dressings and resorbable sutures. Type I collagen was chemically functionalised with 4-vinylbenzyl chloride, enabling UV-induced crosslinking and yielding mechanically robust fibres. Bromothymol blue, a halochromic dye responsive to pH changes, was incorporated via drop-casting to impart visual infection-responsive colour change. Gravimetric analysis and Fourier Transform Infrared Spectroscopy confirmed high dye loading, whereby a Loading Efficiency of 99+/-3 wt.% was achieved. The fibres exhibited controlled swelling in aqueous environments (Swelling Ratio: 323+/-79 - 492+/-73 wt.%) and remarkable wet-state Ultimate Tensile Strength (UTS: 12+/-3 - 15+/-7 MPa), while up to ca. 30 wt.% of their initial crosslinked mass was retained after 24 hours in a collagenase-rich buffer (pH 7.4, 37°C, 2 CDU) and ethanol series dehydration. Importantly, distinct and reversible colour transitions were observed between acidic (pH 5) and alkaline (pH 8) environments, with up to 88 wt.% dye retention following 72-hour incubation. The fibres were successfully processed into woven dressing prototypes and demonstrated knotting ability suitable for suture applications. Overall, these wet-spun collagen fibres integrate infection-responsive capability, biodegradability, and scalable fabrication, representing a promising platform for smart wound dressings and resorbable sutures. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2510_00015 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | An infection-responsive collagen-based wet-spun textile fibre for wound monitoring Gorman, Jonathon Brooker, Charles Li, Xinyu Tronci, Giuseppe Medical Physics Applied Physics Biological Physics Wound infections are a significant clinical and socioeconomic challenge, contributing to delayed healing and increased wound chronicity. To enable early infection detection and inform therapeutic decisions, this study investigated the design of pH-responsive collagen fibres using a scalable wet spinning process, evaluating product suitability for textile dressings and resorbable sutures. Type I collagen was chemically functionalised with 4-vinylbenzyl chloride, enabling UV-induced crosslinking and yielding mechanically robust fibres. Bromothymol blue, a halochromic dye responsive to pH changes, was incorporated via drop-casting to impart visual infection-responsive colour change. Gravimetric analysis and Fourier Transform Infrared Spectroscopy confirmed high dye loading, whereby a Loading Efficiency of 99+/-3 wt.% was achieved. The fibres exhibited controlled swelling in aqueous environments (Swelling Ratio: 323+/-79 - 492+/-73 wt.%) and remarkable wet-state Ultimate Tensile Strength (UTS: 12+/-3 - 15+/-7 MPa), while up to ca. 30 wt.% of their initial crosslinked mass was retained after 24 hours in a collagenase-rich buffer (pH 7.4, 37°C, 2 CDU) and ethanol series dehydration. Importantly, distinct and reversible colour transitions were observed between acidic (pH 5) and alkaline (pH 8) environments, with up to 88 wt.% dye retention following 72-hour incubation. The fibres were successfully processed into woven dressing prototypes and demonstrated knotting ability suitable for suture applications. Overall, these wet-spun collagen fibres integrate infection-responsive capability, biodegradability, and scalable fabrication, representing a promising platform for smart wound dressings and resorbable sutures. |
| title | An infection-responsive collagen-based wet-spun textile fibre for wound monitoring |
| topic | Medical Physics Applied Physics Biological Physics |
| url | https://arxiv.org/abs/2510.00015 |