Selective disruption of reach-related saccade timing following a middle-cerebral artery stroke
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arXiv
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| Format: | Preprint |
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2025
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| author | Beheshti, Mahya Hudson, Todd E Gadde, Rajvardhan Arias, Glenn Alvarez Huh, Karis Sainburg, Robert L Rizzo, JR |
| author_facet | Beheshti, Mahya Hudson, Todd E Gadde, Rajvardhan Arias, Glenn Alvarez Huh, Karis Sainburg, Robert L Rizzo, JR |
| contents | Background: Coordinated control of eye and hand movements is critical for nearly all goal-directed actions, underpinning tasks ranging from simple object manipulation to complex tool use. This coordination relies on temporal coupling between reach and saccade. Stroke disrupts this process at several levels. Methods: We conducted a comparative eye-tracking study on patients with history of stroke vs. control performing various tasks. We used the Kinereach motion-tracking system with integrated eye-tracking functionality for data collection. Results: Stroke participants showed a flat distribution of saccade timing, with no clear peak or alignment to the onset of the reach. In terms of spatial performance, reach gain, the primary index of functional accuracy, revealed that stroke participants reaches were significantly hypometric compared to those of controls. In the segmented look-then-reach condition, stroke participants demonstrated a restoration of a unimodal saccade timing distribution, time-locked to the saccade cue. Conclusion: Our findings highlight a dissociation between motor execution and coordination in stroke, emphasizing that intact movement components do not guarantee intact motor integration. By identifying a reversible, cue-sensitive disruption in saccade timing linked specifically to its coordination within a reaching movement, this work points toward new opportunities for rehabilitation aimed not only at motor strength and speed, but at training and re-establishing the natural temporal structure of action. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2510_03076 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | Selective disruption of reach-related saccade timing following a middle-cerebral artery stroke Beheshti, Mahya Hudson, Todd E Gadde, Rajvardhan Arias, Glenn Alvarez Huh, Karis Sainburg, Robert L Rizzo, JR Neurons and Cognition Background: Coordinated control of eye and hand movements is critical for nearly all goal-directed actions, underpinning tasks ranging from simple object manipulation to complex tool use. This coordination relies on temporal coupling between reach and saccade. Stroke disrupts this process at several levels. Methods: We conducted a comparative eye-tracking study on patients with history of stroke vs. control performing various tasks. We used the Kinereach motion-tracking system with integrated eye-tracking functionality for data collection. Results: Stroke participants showed a flat distribution of saccade timing, with no clear peak or alignment to the onset of the reach. In terms of spatial performance, reach gain, the primary index of functional accuracy, revealed that stroke participants reaches were significantly hypometric compared to those of controls. In the segmented look-then-reach condition, stroke participants demonstrated a restoration of a unimodal saccade timing distribution, time-locked to the saccade cue. Conclusion: Our findings highlight a dissociation between motor execution and coordination in stroke, emphasizing that intact movement components do not guarantee intact motor integration. By identifying a reversible, cue-sensitive disruption in saccade timing linked specifically to its coordination within a reaching movement, this work points toward new opportunities for rehabilitation aimed not only at motor strength and speed, but at training and re-establishing the natural temporal structure of action. |
| title | Selective disruption of reach-related saccade timing following a middle-cerebral artery stroke |
| topic | Neurons and Cognition |
| url | https://arxiv.org/abs/2510.03076 |