Seeing More, Treating Smarter: Role of Long-Axial Field-of-View PET-CT in The Evolution of Theranostics
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arXiv
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| Main Authors: | , , , , , |
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| Format: | Preprint |
| Published: |
2025
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| _version_ | 1866912719483961344 |
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| author | Esquinas, Pedro L. Yousefirizi, Fereshteh Alberts, Ian Karakatsanis, Nicolas A. Rahmim, Arman Uribe, Carlos F. |
| author_facet | Esquinas, Pedro L. Yousefirizi, Fereshteh Alberts, Ian Karakatsanis, Nicolas A. Rahmim, Arman Uribe, Carlos F. |
| contents | Long-axial field-of-view (LAFOV) PET/CT has the potential to redefine the role of molecular imaging in theranostics by making multiparametric whole-body (MPWB) imaging and predictive dosimetry more clinically feasible. Compared to conventional PET systems, LAFOV scanners provide dramatic gains in sensitivity and coverage, allowing dynamic acquisitions, delayed imaging, and dual-tracer protocols within clinically feasible workflows. These advances supply the quantitative data required for physiologically based pharmacokinetic (PBPK) modeling and the creation of theranostic digital twins, supporting true personalization of radiopharmaceutical therapy. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2510_03465 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | Seeing More, Treating Smarter: Role of Long-Axial Field-of-View PET-CT in The Evolution of Theranostics Esquinas, Pedro L. Yousefirizi, Fereshteh Alberts, Ian Karakatsanis, Nicolas A. Rahmim, Arman Uribe, Carlos F. Medical Physics Long-axial field-of-view (LAFOV) PET/CT has the potential to redefine the role of molecular imaging in theranostics by making multiparametric whole-body (MPWB) imaging and predictive dosimetry more clinically feasible. Compared to conventional PET systems, LAFOV scanners provide dramatic gains in sensitivity and coverage, allowing dynamic acquisitions, delayed imaging, and dual-tracer protocols within clinically feasible workflows. These advances supply the quantitative data required for physiologically based pharmacokinetic (PBPK) modeling and the creation of theranostic digital twins, supporting true personalization of radiopharmaceutical therapy. |
| title | Seeing More, Treating Smarter: Role of Long-Axial Field-of-View PET-CT in The Evolution of Theranostics |
| topic | Medical Physics |
| url | https://arxiv.org/abs/2510.03465 |