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Main Authors: Lou, Jincan, Chen, Jingkun, Li, Haoquan, Li, Hang, Huang, Wenjian, Chen, Weihua, Wang, Fan, Zhang, Jianguo
Format: Preprint
Published: 2025
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Online Access:https://arxiv.org/abs/2510.04243
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author Lou, Jincan
Chen, Jingkun
Li, Haoquan
Li, Hang
Huang, Wenjian
Chen, Weihua
Wang, Fan
Zhang, Jianguo
author_facet Lou, Jincan
Chen, Jingkun
Li, Haoquan
Li, Hang
Huang, Wenjian
Chen, Weihua
Wang, Fan
Zhang, Jianguo
contents Accurate liver segmentation from contrast-enhanced MRI is essential for diagnosis, treatment planning, and disease monitoring. However, it remains challenging due to limited annotated data, heterogeneous enhancement protocols, and significant domain shifts across scanners and institutions. Traditional image-to-image translation frameworks have made great progress in domain generalization, but their application is not straightforward. For example, Pix2Pix requires image registration, and cycle-GAN cannot be integrated seamlessly into segmentation pipelines. Meanwhile, these methods are originally used to deal with cross-modality scenarios, and often introduce structural distortions and suffer from unstable training, which may pose drawbacks in our single-modality scenario. To address these challenges, we propose CoSSeg-TTA, a compact segmentation framework for the GED4 (Gd-EOB-DTPA enhanced hepatobiliary phase MRI) modality built upon nnU-Netv2 and enhanced with a semi-supervised mean teacher scheme to exploit large amounts of unlabeled volumes. A domain adaptation module, incorporating a randomized histogram-based style appearance transfer function and a trainable contrast-aware network, enriches domain diversity and mitigates cross-center variability. Furthermore, a continual test-time adaptation strategy is employed to improve robustness during inference. Extensive experiments demonstrate that our framework consistently outperforms the nnU-Netv2 baseline, achieving superior Dice score and Hausdorff Distance while exhibiting strong generalization to unseen domains under low-annotation conditions.
format Preprint
id arxiv_https___arxiv_org_abs_2510_04243
institution arXiv
publishDate 2025
record_format arxiv
spellingShingle The 1st Solution for CARE Liver Task Challenge 2025: Contrast-Aware Semi-Supervised Segmentation with Domain Generalization and Test-Time Adaptation
Lou, Jincan
Chen, Jingkun
Li, Haoquan
Li, Hang
Huang, Wenjian
Chen, Weihua
Wang, Fan
Zhang, Jianguo
Computer Vision and Pattern Recognition
Accurate liver segmentation from contrast-enhanced MRI is essential for diagnosis, treatment planning, and disease monitoring. However, it remains challenging due to limited annotated data, heterogeneous enhancement protocols, and significant domain shifts across scanners and institutions. Traditional image-to-image translation frameworks have made great progress in domain generalization, but their application is not straightforward. For example, Pix2Pix requires image registration, and cycle-GAN cannot be integrated seamlessly into segmentation pipelines. Meanwhile, these methods are originally used to deal with cross-modality scenarios, and often introduce structural distortions and suffer from unstable training, which may pose drawbacks in our single-modality scenario. To address these challenges, we propose CoSSeg-TTA, a compact segmentation framework for the GED4 (Gd-EOB-DTPA enhanced hepatobiliary phase MRI) modality built upon nnU-Netv2 and enhanced with a semi-supervised mean teacher scheme to exploit large amounts of unlabeled volumes. A domain adaptation module, incorporating a randomized histogram-based style appearance transfer function and a trainable contrast-aware network, enriches domain diversity and mitigates cross-center variability. Furthermore, a continual test-time adaptation strategy is employed to improve robustness during inference. Extensive experiments demonstrate that our framework consistently outperforms the nnU-Netv2 baseline, achieving superior Dice score and Hausdorff Distance while exhibiting strong generalization to unseen domains under low-annotation conditions.
title The 1st Solution for CARE Liver Task Challenge 2025: Contrast-Aware Semi-Supervised Segmentation with Domain Generalization and Test-Time Adaptation
topic Computer Vision and Pattern Recognition
url https://arxiv.org/abs/2510.04243