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| Main Authors: | , , , , |
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| Format: | Preprint |
| Published: |
2025
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| Subjects: | |
| Online Access: | https://arxiv.org/abs/2510.06022 |
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| _version_ | 1866911196099117056 |
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| author | Jang, Albert Jang, Hyungseok Wang, Nian Samsonov, Alexey Liu, Fang |
| author_facet | Jang, Albert Jang, Hyungseok Wang, Nian Samsonov, Alexey Liu, Fang |
| contents | We propose a signal acquisition and modeling framework for multi-component tissue quantification that encompasses transmit field inhomogeneity, multi-component relaxation and magnetization transfer (MT) effects. By applying off-resonance irradiation between excitation and acquisition within an RF-spoiled gradient-echo scheme, in combination with multiple echo-time acquisitions, both Bloch-Siegert shift and magnetization transfer effects are simultaneously induced while relaxation and spin exchange processes occur concurrently. Simulation results showed excellent agreement with the derived analytical signal equation across a wide range of flip angles and echo times. Monte Carlo analyses further validated that the three-pool parameter estimation pipeline performed robustly over various signal-to-noise ratio conditions. Multi-parameter fitting results from in vivo brain and knee studies yielded values consistent with previously reported literature. Collectively, these findings confirm that the proposed method can reliably characterize multi-component tissue parameters in macromolecule-rich environments while effectively compensating for $B_1^+$ inhomogeneity. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2510_06022 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | MC BTS: simultaneously resolving magnetization transfer effect and relaxation for multiple components Jang, Albert Jang, Hyungseok Wang, Nian Samsonov, Alexey Liu, Fang Medical Physics We propose a signal acquisition and modeling framework for multi-component tissue quantification that encompasses transmit field inhomogeneity, multi-component relaxation and magnetization transfer (MT) effects. By applying off-resonance irradiation between excitation and acquisition within an RF-spoiled gradient-echo scheme, in combination with multiple echo-time acquisitions, both Bloch-Siegert shift and magnetization transfer effects are simultaneously induced while relaxation and spin exchange processes occur concurrently. Simulation results showed excellent agreement with the derived analytical signal equation across a wide range of flip angles and echo times. Monte Carlo analyses further validated that the three-pool parameter estimation pipeline performed robustly over various signal-to-noise ratio conditions. Multi-parameter fitting results from in vivo brain and knee studies yielded values consistent with previously reported literature. Collectively, these findings confirm that the proposed method can reliably characterize multi-component tissue parameters in macromolecule-rich environments while effectively compensating for $B_1^+$ inhomogeneity. |
| title | MC BTS: simultaneously resolving magnetization transfer effect and relaxation for multiple components |
| topic | Medical Physics |
| url | https://arxiv.org/abs/2510.06022 |