On Assessing Overall Survival (OS) in Oncology Studies
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arXiv
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| Format: | Preprint |
| Published: |
2025
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| _version_ | 1866912720055435264 |
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| author | Hsu, Jason C. |
| author_facet | Hsu, Jason C. |
| contents | In assessing Overall Survival (OS) in oncology studies, it is essential for the efficacy measure to be Logic-respecting, for otherwise patients may be incorrectly targeted. This paper explains, while Time Ratio (TR) is Logic-respecting, Hazard Ratio (HR) is not Logic-respecting. With Time Ratio (TR) being recommended, a smooth transitioning strategy is suggested. The conclusion states: Logicality requires, and Subgroup Mixable Estimation (SME) delivers, an efficacy assessment for the overall population within the range of minimum and maximum efficacy in the subgroups, no matter how outcome is measured, whichever logic-respecting efficacy measure is chosen, the same efficacy assessment regardless of how subgroups are stratified. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2510_07122 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | On Assessing Overall Survival (OS) in Oncology Studies Hsu, Jason C. Methodology Applications In assessing Overall Survival (OS) in oncology studies, it is essential for the efficacy measure to be Logic-respecting, for otherwise patients may be incorrectly targeted. This paper explains, while Time Ratio (TR) is Logic-respecting, Hazard Ratio (HR) is not Logic-respecting. With Time Ratio (TR) being recommended, a smooth transitioning strategy is suggested. The conclusion states: Logicality requires, and Subgroup Mixable Estimation (SME) delivers, an efficacy assessment for the overall population within the range of minimum and maximum efficacy in the subgroups, no matter how outcome is measured, whichever logic-respecting efficacy measure is chosen, the same efficacy assessment regardless of how subgroups are stratified. |
| title | On Assessing Overall Survival (OS) in Oncology Studies |
| topic | Methodology Applications |
| url | https://arxiv.org/abs/2510.07122 |