Graphene nanowindows as a basis for creating mechanically robust nanohydroxyapatite bone lamellar scaffolds
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arXiv
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| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Preprint |
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2025
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| _version_ | 1866915541648670720 |
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| author | Kukobat, Radovan Škrbić, Ranko Jovičić, Sanja Matičić, Milka Stojmenovski, Aneta Bulajić, Marko Marin, Saša Bodroža, Darko Stević, Dragana Atlagić, Suzana Gotovac Ignjatović, Nenad Vallejos-Burgos, Fernando Mercadelli, Elisa Ponti, Jessica Fumagalli, Francesco Valsesia, Andrea |
| author_facet | Kukobat, Radovan Škrbić, Ranko Jovičić, Sanja Matičić, Milka Stojmenovski, Aneta Bulajić, Marko Marin, Saša Bodroža, Darko Stević, Dragana Atlagić, Suzana Gotovac Ignjatović, Nenad Vallejos-Burgos, Fernando Mercadelli, Elisa Ponti, Jessica Fumagalli, Francesco Valsesia, Andrea |
| contents | The role of graphene nanowindows in the nanohydroxyapatite bone scaffold preparation is important for the preparation of mechanically robust scaffolds and implementation in bone recovery. Here, we report a graphene-nanohydroxyapatite (G-nHAP) scaffold synthesized by the hydrothermal method, along with its formation mechanism and promising in vivo applications. The G-nHAP scaffold exhibits excellent mechanical strength comparable to that of cancellous bone. The nHAP was grown on 2D layers of graphene with nanowindows. The role of nanowindows was to attract electrostatically Ca2+, PO43+, and OH- precursors of nHAP, forming a layered structure of G-nHAP, in which nHAP nanorods of 23.8 nm in diameter and 84.7 nm in length were placed between graphene layers, as evidenced with molecular dynamic simulations. In vivo study showed mature and mineralized bone and osteoid after six weeks. This demonstrates the role of graphene nanowindows in the formation of nHAP scaffolds that are promising for future implementation in bone tissue regeneration. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2510_07850 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | Graphene nanowindows as a basis for creating mechanically robust nanohydroxyapatite bone lamellar scaffolds Kukobat, Radovan Škrbić, Ranko Jovičić, Sanja Matičić, Milka Stojmenovski, Aneta Bulajić, Marko Marin, Saša Bodroža, Darko Stević, Dragana Atlagić, Suzana Gotovac Ignjatović, Nenad Vallejos-Burgos, Fernando Mercadelli, Elisa Ponti, Jessica Fumagalli, Francesco Valsesia, Andrea Chemical Physics The role of graphene nanowindows in the nanohydroxyapatite bone scaffold preparation is important for the preparation of mechanically robust scaffolds and implementation in bone recovery. Here, we report a graphene-nanohydroxyapatite (G-nHAP) scaffold synthesized by the hydrothermal method, along with its formation mechanism and promising in vivo applications. The G-nHAP scaffold exhibits excellent mechanical strength comparable to that of cancellous bone. The nHAP was grown on 2D layers of graphene with nanowindows. The role of nanowindows was to attract electrostatically Ca2+, PO43+, and OH- precursors of nHAP, forming a layered structure of G-nHAP, in which nHAP nanorods of 23.8 nm in diameter and 84.7 nm in length were placed between graphene layers, as evidenced with molecular dynamic simulations. In vivo study showed mature and mineralized bone and osteoid after six weeks. This demonstrates the role of graphene nanowindows in the formation of nHAP scaffolds that are promising for future implementation in bone tissue regeneration. |
| title | Graphene nanowindows as a basis for creating mechanically robust nanohydroxyapatite bone lamellar scaffolds |
| topic | Chemical Physics |
| url | https://arxiv.org/abs/2510.07850 |