A Biophysically-Conditioned Generative Framework for 3D Brain Tumor MRI Synthesis
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arXiv
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| Main Authors: | , , , , , , |
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| Format: | Preprint |
| Published: |
2025
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| _version_ | 1866914187142234112 |
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| author | Biller, Valentin Zimmer, Lucas Erdur, Ayhan Can Nagar, Sandeep Rückert, Daniel Bubeck, Niklas Weidner, Jonas |
| author_facet | Biller, Valentin Zimmer, Lucas Erdur, Ayhan Can Nagar, Sandeep Rückert, Daniel Bubeck, Niklas Weidner, Jonas |
| contents | Magnetic resonance imaging (MRI) inpainting supports numerous clinical and research applications. We introduce the first generative model that conditions on voxel-level, continuous tumor concentrations to synthesize high-fidelity brain tumor MRIs. For the BraTS 2025 Inpainting Challenge, we adapt this architecture to the complementary task of healthy tissue restoration by setting the tumor concentrations to zero. Our latent diffusion model conditioned on both tissue segmentations and the tumor concentrations generates 3D spatially coherent and anatomically consistent images for both tumor synthesis and healthy tissue inpainting. For healthy inpainting, we achieve a PSNR of 18.5, and for tumor inpainting, we achieve 17.4. Our code is available at: https://github.com/valentin-biller/ldm.git |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2510_09365 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | A Biophysically-Conditioned Generative Framework for 3D Brain Tumor MRI Synthesis Biller, Valentin Zimmer, Lucas Erdur, Ayhan Can Nagar, Sandeep Rückert, Daniel Bubeck, Niklas Weidner, Jonas Image and Video Processing Computer Vision and Pattern Recognition Machine Learning Magnetic resonance imaging (MRI) inpainting supports numerous clinical and research applications. We introduce the first generative model that conditions on voxel-level, continuous tumor concentrations to synthesize high-fidelity brain tumor MRIs. For the BraTS 2025 Inpainting Challenge, we adapt this architecture to the complementary task of healthy tissue restoration by setting the tumor concentrations to zero. Our latent diffusion model conditioned on both tissue segmentations and the tumor concentrations generates 3D spatially coherent and anatomically consistent images for both tumor synthesis and healthy tissue inpainting. For healthy inpainting, we achieve a PSNR of 18.5, and for tumor inpainting, we achieve 17.4. Our code is available at: https://github.com/valentin-biller/ldm.git |
| title | A Biophysically-Conditioned Generative Framework for 3D Brain Tumor MRI Synthesis |
| topic | Image and Video Processing Computer Vision and Pattern Recognition Machine Learning |
| url | https://arxiv.org/abs/2510.09365 |