Tumor Obliteration by Resonant Amplification (TOR) A Nonthermal, Spectrally-Targeted Approach to Cancer Disintegration
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2025
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| author | Mello, Cesar da Cunha, Fernando Medina |
| author_facet | Mello, Cesar da Cunha, Fernando Medina |
| contents | Tumor Obliteration by Resonant Amplification (TOR) was evaluated purely in simulation. Forward models in COMSOL, ANSYS, and ABAQUS used the same small-strain rheology, nonthermal/noncavitational limits, and an emulated closed loop (phase-locked actuation plus contrast/safety gating). Over >= 200 Monte Carlo runs per setup, TOR produced per-focus extinction in 2.6-3.2 s at approx. 0.85-0.90 J/cm^3, with selectivity Q = 39 +/- 5, peak temperature rise dT_max <= 0.2 deg C, and CEM43 << 1, consistent with strictly nonthermal operation. Primary indices indicated high spectral fidelity and intrinsic safety margin: MMI = 0.92 +/- 0.03, SSR = 14.6 +/- 3.1 (circumscribed) / 11.2 +/- 2.4 (infiltrative), and ATI <= 0.8 of the matrix-failure threshold. Simulated foci matched FE predictions within +/- 150 um.
A unitless reality-adherence score comparing four observables to consolidated literature ranges yielded A = 95% +/- 2% (BCa 95%). Organ-specific estimates were 95.1% (pancreatic ductal adenocarcinoma), 96.0% (prostatic acinar adenocarcinoma), and 94.2% (invasive ductal carcinoma of the breast). The delivery stack - tungsten micro-needle (300-500 um) with 5-25 um tip excursions, phase lock, and amplitude gating - operated in a small-strain, noncavitational regime, keeping off-target strain below safety limits by design.
Mechanistically, mode-selective collapse implies suppression of core vesicle biogenesis and nociceptor drive; rim scanning is constrained by healthy-referenced bounds, motivating compact neuroimmune readouts in future tests. Overall, the calibrated multiphysics results support a reproducible, spectrum-locked path from modeling to benchtop: deterministic extinction at low energy, high selectivity, and strict thermal neutrality, with pre-registered experiments planned to confirm the predicted safety and efficacy envelopes. |
| format | Preprint |
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arxiv_https___arxiv_org_abs_2510_09982 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | Tumor Obliteration by Resonant Amplification (TOR) A Nonthermal, Spectrally-Targeted Approach to Cancer Disintegration Mello, Cesar da Cunha, Fernando Medina Medical Physics 74H45 Tumor Obliteration by Resonant Amplification (TOR) was evaluated purely in simulation. Forward models in COMSOL, ANSYS, and ABAQUS used the same small-strain rheology, nonthermal/noncavitational limits, and an emulated closed loop (phase-locked actuation plus contrast/safety gating). Over >= 200 Monte Carlo runs per setup, TOR produced per-focus extinction in 2.6-3.2 s at approx. 0.85-0.90 J/cm^3, with selectivity Q = 39 +/- 5, peak temperature rise dT_max <= 0.2 deg C, and CEM43 << 1, consistent with strictly nonthermal operation. Primary indices indicated high spectral fidelity and intrinsic safety margin: MMI = 0.92 +/- 0.03, SSR = 14.6 +/- 3.1 (circumscribed) / 11.2 +/- 2.4 (infiltrative), and ATI <= 0.8 of the matrix-failure threshold. Simulated foci matched FE predictions within +/- 150 um. A unitless reality-adherence score comparing four observables to consolidated literature ranges yielded A = 95% +/- 2% (BCa 95%). Organ-specific estimates were 95.1% (pancreatic ductal adenocarcinoma), 96.0% (prostatic acinar adenocarcinoma), and 94.2% (invasive ductal carcinoma of the breast). The delivery stack - tungsten micro-needle (300-500 um) with 5-25 um tip excursions, phase lock, and amplitude gating - operated in a small-strain, noncavitational regime, keeping off-target strain below safety limits by design. Mechanistically, mode-selective collapse implies suppression of core vesicle biogenesis and nociceptor drive; rim scanning is constrained by healthy-referenced bounds, motivating compact neuroimmune readouts in future tests. Overall, the calibrated multiphysics results support a reproducible, spectrum-locked path from modeling to benchtop: deterministic extinction at low energy, high selectivity, and strict thermal neutrality, with pre-registered experiments planned to confirm the predicted safety and efficacy envelopes. |
| title | Tumor Obliteration by Resonant Amplification (TOR) A Nonthermal, Spectrally-Targeted Approach to Cancer Disintegration |
| topic | Medical Physics 74H45 |
| url | https://arxiv.org/abs/2510.09982 |