Formulation and Therapeutic Assessment of a Zinc Oxide, Silver, and Cerium Oxide Enriched Ointment for Accelerated Wound Healing in Aged Models
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arXiv
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| Format: | Preprint |
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2025
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| _version_ | 1866909840324952064 |
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| author | Yousaf, Iqra Anwar, Aneela Umer, Atika |
| author_facet | Yousaf, Iqra Anwar, Aneela Umer, Atika |
| contents | Chronic wounds present a major challenge in elderly individuals due to diminished regenerative capacity and impaired tissue repair mechanisms associated with aging. In this study, we formulated a topical gel composed of zinc oxide (ZnO), silver (Ag), and cerium oxide (CeO2) nanoparticles, each chosen for their respective antimicrobial, antioxidant, and tissue-regenerative properties. The nanoparticles were synthesized through precise precipitation or reduction techniques and thoroughly characterized using UV-Vis spectroscopy, dynamic light scattering (DLS), Fourier-transform infrared spectroscopy (FTIR), and electron microscopy to confirm nanoscale structure and purity. An in vivo wound healing model utilizing aged Sprague-Dawley rats was employed, with animals divided into three groups: untreated, placebo-treated, and those receiving the nanoparticle-enriched gel. Wound dimensions were tracked for 14 days, revealing significantly improved healing in the nanoparticle-treated group, with nearly complete closure observed by day 14 (ANOVA, p less than 0.0001). Cytocompatibility was assessed via MTT assay on L929 fibroblasts, confirming greater than 80 percent viability at therapeutically relevant concentrations. These findings underscore the potential of multifunctional nanoparticle-based formulations to enhance wound healing in aged or compromised skin environments, offering a promising therapeutic avenue. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2510_10717 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | Formulation and Therapeutic Assessment of a Zinc Oxide, Silver, and Cerium Oxide Enriched Ointment for Accelerated Wound Healing in Aged Models Yousaf, Iqra Anwar, Aneela Umer, Atika Medical Physics Biological Physics 68T07, 68T05 I.2.6; I.6.4 Chronic wounds present a major challenge in elderly individuals due to diminished regenerative capacity and impaired tissue repair mechanisms associated with aging. In this study, we formulated a topical gel composed of zinc oxide (ZnO), silver (Ag), and cerium oxide (CeO2) nanoparticles, each chosen for their respective antimicrobial, antioxidant, and tissue-regenerative properties. The nanoparticles were synthesized through precise precipitation or reduction techniques and thoroughly characterized using UV-Vis spectroscopy, dynamic light scattering (DLS), Fourier-transform infrared spectroscopy (FTIR), and electron microscopy to confirm nanoscale structure and purity. An in vivo wound healing model utilizing aged Sprague-Dawley rats was employed, with animals divided into three groups: untreated, placebo-treated, and those receiving the nanoparticle-enriched gel. Wound dimensions were tracked for 14 days, revealing significantly improved healing in the nanoparticle-treated group, with nearly complete closure observed by day 14 (ANOVA, p less than 0.0001). Cytocompatibility was assessed via MTT assay on L929 fibroblasts, confirming greater than 80 percent viability at therapeutically relevant concentrations. These findings underscore the potential of multifunctional nanoparticle-based formulations to enhance wound healing in aged or compromised skin environments, offering a promising therapeutic avenue. |
| title | Formulation and Therapeutic Assessment of a Zinc Oxide, Silver, and Cerium Oxide Enriched Ointment for Accelerated Wound Healing in Aged Models |
| topic | Medical Physics Biological Physics 68T07, 68T05 I.2.6; I.6.4 |
| url | https://arxiv.org/abs/2510.10717 |