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| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Preprint |
| Published: |
2025
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| Subjects: | |
| Online Access: | https://arxiv.org/abs/2510.12854 |
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| _version_ | 1866917014911582208 |
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| author | Xing, Na Er, Jasmin Vidal, Ricardo M. Khadka, Sandhya Schusterbauer, Robert Rosentreter, Maik Etouki, Ranen Ahmed, Rameez Page, Taylor Nickl, Philip Bawadkji, Obida Wiesner, Anja Radnik, Joerg Hodoroaba, Vasile-Dan Ludwig, Kai Trimpert, Jakob Donskyi, Ievgen S. |
| author_facet | Xing, Na Er, Jasmin Vidal, Ricardo M. Khadka, Sandhya Schusterbauer, Robert Rosentreter, Maik Etouki, Ranen Ahmed, Rameez Page, Taylor Nickl, Philip Bawadkji, Obida Wiesner, Anja Radnik, Joerg Hodoroaba, Vasile-Dan Ludwig, Kai Trimpert, Jakob Donskyi, Ievgen S. |
| contents | At the onset of viral outbreaks, broad-spectrum antiviral materials are crucial before specific therapeutics become available. We report scalable, biodegradable black phosphorus (BP) hybrids that provide mutation-resilient virucidal protection. BP sheets, produced via an optimized mechanochemical process, are covalently functionalized with 2-azido-4,6-dichloro- 1,3,5-triazine to form P=N bonds. Fucoidan, a sulfated polysaccharide with intrinsic antiviral activity, and hydrophobic chains are then incorporated to achieve irreversible viral deactivation. The material exhibits strong antiviral inhibition and complete virucidal activity against multiple viruses, including recent severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants. It maintains high biocompatibility, remains effective against viral mutations, and is shelf stable for at least five month. The combination of biodegradability, scalable synthesis, and synergistic antiviral and virucidal mechanisms establishes BP-conjugates as a new class of highly efficient antivirals. They offer a broad spectrum antiviral solutions that could bridge the gap between antiviral medicines and general antiseptics. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2510_12854 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | Scalable covalently functionalized black phosphorus hybrids for broadspectrum virucidal activity Xing, Na Er, Jasmin Vidal, Ricardo M. Khadka, Sandhya Schusterbauer, Robert Rosentreter, Maik Etouki, Ranen Ahmed, Rameez Page, Taylor Nickl, Philip Bawadkji, Obida Wiesner, Anja Radnik, Joerg Hodoroaba, Vasile-Dan Ludwig, Kai Trimpert, Jakob Donskyi, Ievgen S. Medical Physics Materials Science At the onset of viral outbreaks, broad-spectrum antiviral materials are crucial before specific therapeutics become available. We report scalable, biodegradable black phosphorus (BP) hybrids that provide mutation-resilient virucidal protection. BP sheets, produced via an optimized mechanochemical process, are covalently functionalized with 2-azido-4,6-dichloro- 1,3,5-triazine to form P=N bonds. Fucoidan, a sulfated polysaccharide with intrinsic antiviral activity, and hydrophobic chains are then incorporated to achieve irreversible viral deactivation. The material exhibits strong antiviral inhibition and complete virucidal activity against multiple viruses, including recent severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants. It maintains high biocompatibility, remains effective against viral mutations, and is shelf stable for at least five month. The combination of biodegradability, scalable synthesis, and synergistic antiviral and virucidal mechanisms establishes BP-conjugates as a new class of highly efficient antivirals. They offer a broad spectrum antiviral solutions that could bridge the gap between antiviral medicines and general antiseptics. |
| title | Scalable covalently functionalized black phosphorus hybrids for broadspectrum virucidal activity |
| topic | Medical Physics Materials Science |
| url | https://arxiv.org/abs/2510.12854 |