Control of Neuronal Survival and Development Using Conductive Diamond
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arXiv
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| Autores principales: | , , , , , , , , , , , , , , , |
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| Formato: | Preprint |
| Publicado: |
2025
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| _version_ | 1866917020800385024 |
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| author | Falahatdoost, Samira Prawer, Yair D. J. Peng, Danli Chambers, Andre Zhan, Hualin Pope, Leon Stacey, Alastair Ahnood, Arman Hashem, Hassan N. Al De Leon, Sorel E. Garrett, David J. Fox, Kate Clark, Michael B. Ibbotson, Michael R. Prawer, Steven Tong, Wei |
| author_facet | Falahatdoost, Samira Prawer, Yair D. J. Peng, Danli Chambers, Andre Zhan, Hualin Pope, Leon Stacey, Alastair Ahnood, Arman Hashem, Hassan N. Al De Leon, Sorel E. Garrett, David J. Fox, Kate Clark, Michael B. Ibbotson, Michael R. Prawer, Steven Tong, Wei |
| contents | This study demonstrates the control of neuronal survival and development using nitrogen-doped ultrananocrystalline diamond (N-UNCD). We highlight the role of N-UNCD in regulating neuronal activity via near-infrared illumination, demonstrating the generation of stable photocurrents that enhance neuronal survival and neurite outgrowth and foster a more active, synchronized neuronal network. Whole transcriptome RNA sequencing reveals that diamond substrates improve cellular-substrate interaction by upregulating extracellular matrix and gap junction-related genes. Our findings underscore the potential of conductive diamond as a robust and biocompatible platform for noninvasive and effective neural tissue engineering. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2510_14994 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | Control of Neuronal Survival and Development Using Conductive Diamond Falahatdoost, Samira Prawer, Yair D. J. Peng, Danli Chambers, Andre Zhan, Hualin Pope, Leon Stacey, Alastair Ahnood, Arman Hashem, Hassan N. Al De Leon, Sorel E. Garrett, David J. Fox, Kate Clark, Michael B. Ibbotson, Michael R. Prawer, Steven Tong, Wei Biological Physics Materials Science Applied Physics This study demonstrates the control of neuronal survival and development using nitrogen-doped ultrananocrystalline diamond (N-UNCD). We highlight the role of N-UNCD in regulating neuronal activity via near-infrared illumination, demonstrating the generation of stable photocurrents that enhance neuronal survival and neurite outgrowth and foster a more active, synchronized neuronal network. Whole transcriptome RNA sequencing reveals that diamond substrates improve cellular-substrate interaction by upregulating extracellular matrix and gap junction-related genes. Our findings underscore the potential of conductive diamond as a robust and biocompatible platform for noninvasive and effective neural tissue engineering. |
| title | Control of Neuronal Survival and Development Using Conductive Diamond |
| topic | Biological Physics Materials Science Applied Physics |
| url | https://arxiv.org/abs/2510.14994 |