Guardado en:
| Autor principal: | |
|---|---|
| Formato: | Preprint |
| Publicado: |
2025
|
| Materias: | |
| Acceso en línea: | https://arxiv.org/abs/2510.15837 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| _version_ | 1866912655069937664 |
|---|---|
| author | Singh, Vikash |
| author_facet | Singh, Vikash |
| contents | We present Transfer Orthology Networks (TRON), a novel neural network architecture designed for cross-species transfer learning. TRON leverages orthologous relationships, represented as a bipartite graph between species, to guide knowledge transfer. Specifically, we prepend a learned species conversion layer, whose weights are masked by the biadjacency matrix of this bipartite graph, to a pre-trained feedforward neural network that predicts a phenotype from gene expression data in a source species. This allows for efficient transfer of knowledge to a target species by learning a linear transformation that maps gene expression from the source to the target species' gene space. The learned weights of this conversion layer offer a potential avenue for interpreting functional orthology, providing insights into how genes across species contribute to the phenotype of interest. TRON offers a biologically grounded and interpretable approach to cross-species transfer learning, paving the way for more effective utilization of available transcriptomic data. We are in the process of collecting cross-species transcriptomic/phenotypic data to gain experimental validation of the TRON architecture. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2510_15837 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | Transfer Orthology Networks Singh, Vikash Machine Learning We present Transfer Orthology Networks (TRON), a novel neural network architecture designed for cross-species transfer learning. TRON leverages orthologous relationships, represented as a bipartite graph between species, to guide knowledge transfer. Specifically, we prepend a learned species conversion layer, whose weights are masked by the biadjacency matrix of this bipartite graph, to a pre-trained feedforward neural network that predicts a phenotype from gene expression data in a source species. This allows for efficient transfer of knowledge to a target species by learning a linear transformation that maps gene expression from the source to the target species' gene space. The learned weights of this conversion layer offer a potential avenue for interpreting functional orthology, providing insights into how genes across species contribute to the phenotype of interest. TRON offers a biologically grounded and interpretable approach to cross-species transfer learning, paving the way for more effective utilization of available transcriptomic data. We are in the process of collecting cross-species transcriptomic/phenotypic data to gain experimental validation of the TRON architecture. |
| title | Transfer Orthology Networks |
| topic | Machine Learning |
| url | https://arxiv.org/abs/2510.15837 |