DARE: A Deformable Adaptive Regularization Estimator for Learning-Based Medical Image Registration

Fuente: arXiv
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Auteurs principaux: Siyal, Ahsan Raza, Haltmeier, Markus, Steiger, Ruth, Galijasevic, Malik, Gizewski, Elke Ruth, Grams, Astrid Ellen
Format: Preprint
Publié: 2025
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author Siyal, Ahsan Raza
Haltmeier, Markus
Steiger, Ruth
Galijasevic, Malik
Gizewski, Elke Ruth
Grams, Astrid Ellen
author_facet Siyal, Ahsan Raza
Haltmeier, Markus
Steiger, Ruth
Galijasevic, Malik
Gizewski, Elke Ruth
Grams, Astrid Ellen
contents Deformable medical image registration is a fundamental task in medical image analysis. While deep learning-based methods have demonstrated superior accuracy and computational efficiency compared to traditional techniques, they often overlook the critical role of regularization in ensuring robustness and anatomical plausibility. We propose DARE (Deformable Adaptive Regularization Estimator), a novel registration framework that dynamically adjusts elastic regularization based on the gradient norm of the deformation field. Our approach integrates strain and shear energy terms, which are adaptively modulated to balance stability and flexibility. To ensure physically realistic transformations, DARE includes a folding-prevention mechanism that penalizes regions with negative deformation Jacobian. This strategy mitigates non-physical artifacts such as folding, avoids over-smoothing, and improves both registration accuracy and anatomical plausibility
format Preprint
id arxiv_https___arxiv_org_abs_2510_19353
institution arXiv
publishDate 2025
record_format arxiv
spellingShingle DARE: A Deformable Adaptive Regularization Estimator for Learning-Based Medical Image Registration
Siyal, Ahsan Raza
Haltmeier, Markus
Steiger, Ruth
Galijasevic, Malik
Gizewski, Elke Ruth
Grams, Astrid Ellen
Computer Vision and Pattern Recognition
Numerical Analysis
Deformable medical image registration is a fundamental task in medical image analysis. While deep learning-based methods have demonstrated superior accuracy and computational efficiency compared to traditional techniques, they often overlook the critical role of regularization in ensuring robustness and anatomical plausibility. We propose DARE (Deformable Adaptive Regularization Estimator), a novel registration framework that dynamically adjusts elastic regularization based on the gradient norm of the deformation field. Our approach integrates strain and shear energy terms, which are adaptively modulated to balance stability and flexibility. To ensure physically realistic transformations, DARE includes a folding-prevention mechanism that penalizes regions with negative deformation Jacobian. This strategy mitigates non-physical artifacts such as folding, avoids over-smoothing, and improves both registration accuracy and anatomical plausibility
title DARE: A Deformable Adaptive Regularization Estimator for Learning-Based Medical Image Registration
topic Computer Vision and Pattern Recognition
Numerical Analysis
url https://arxiv.org/abs/2510.19353