MedReason-R1: Learning to Reason for CT Diagnosis with Reinforcement Learning and Local Zoom

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Main Authors: Li, Yifan, Tang, Fenghe, Li, Yingtai, Zhou, Shaohua Kevin
Format: Preprint
Published: 2025
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author Li, Yifan
Tang, Fenghe
Li, Yingtai
Zhou, Shaohua Kevin
author_facet Li, Yifan
Tang, Fenghe
Li, Yingtai
Zhou, Shaohua Kevin
contents General-purpose large Vision-Language Models (VLMs) demonstrate strong capabilities in generating detailed descriptions for natural images. However, their performance in the medical domain remains suboptimal, even for relatively straightforward tasks, primarily due to the lack of large-scale, high-quality, specialized medical imaging datasets and the neglect of the diagnostic process that progresses from coarse to fine-grained. To address the first issue, we construct the CT-RATE-VQA dataset, which has 84K QA pairs. For the second issue, we propose MedReason-R1, a medical VLM with explicit reasoning process for disease diagnosis. MedReason-R1 incorporates a novel strategy that embeds zoom-in disease region-of-interest areas into the image, highlighting the crucial role of both global localization and disease-specific details in enhancing the model's diagnostic performance. Furthermore, we introduce the GRPO reinforcement learning framework to MedReason-R1, which enables effective reasoning without relying on costly manual annotations. Compared to recent general-purpose and medical VLMs, MedReason-R1 achieves state-of-the-art performance in CT disease diagnosis while retaining generalization. The code, checkpoints, and dataset are available at: https://github.com/Leevan001/MedReason-R1
format Preprint
id arxiv_https___arxiv_org_abs_2510_19626
institution arXiv
publishDate 2025
record_format arxiv
spellingShingle MedReason-R1: Learning to Reason for CT Diagnosis with Reinforcement Learning and Local Zoom
Li, Yifan
Tang, Fenghe
Li, Yingtai
Zhou, Shaohua Kevin
Computer Vision and Pattern Recognition
General-purpose large Vision-Language Models (VLMs) demonstrate strong capabilities in generating detailed descriptions for natural images. However, their performance in the medical domain remains suboptimal, even for relatively straightforward tasks, primarily due to the lack of large-scale, high-quality, specialized medical imaging datasets and the neglect of the diagnostic process that progresses from coarse to fine-grained. To address the first issue, we construct the CT-RATE-VQA dataset, which has 84K QA pairs. For the second issue, we propose MedReason-R1, a medical VLM with explicit reasoning process for disease diagnosis. MedReason-R1 incorporates a novel strategy that embeds zoom-in disease region-of-interest areas into the image, highlighting the crucial role of both global localization and disease-specific details in enhancing the model's diagnostic performance. Furthermore, we introduce the GRPO reinforcement learning framework to MedReason-R1, which enables effective reasoning without relying on costly manual annotations. Compared to recent general-purpose and medical VLMs, MedReason-R1 achieves state-of-the-art performance in CT disease diagnosis while retaining generalization. The code, checkpoints, and dataset are available at: https://github.com/Leevan001/MedReason-R1
title MedReason-R1: Learning to Reason for CT Diagnosis with Reinforcement Learning and Local Zoom
topic Computer Vision and Pattern Recognition
url https://arxiv.org/abs/2510.19626