T2 mapping at 0.55 T using Ultra-Fast Spin Echo MRI
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2025
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| author | Roulet, Margaux Kebiri, Hamza Bulut, Busra Zalevskyi, Vladyslav Sanchez, Thomas Ledoux, Jean-Baptiste Dunet, Vincent Koob, Mériam Hilbert, Tom Kober, Tobias Canales-Rodriguez, Erick J Cuadra, Meritxell Bach |
| author_facet | Roulet, Margaux Kebiri, Hamza Bulut, Busra Zalevskyi, Vladyslav Sanchez, Thomas Ledoux, Jean-Baptiste Dunet, Vincent Koob, Mériam Hilbert, Tom Kober, Tobias Canales-Rodriguez, Erick J Cuadra, Meritxell Bach |
| contents | Low-field T2 mapping MRI can democratize neuropediatric imaging by improving accessibility and providing quantitative biomarkers of brain development. \textbf{Purpose:} To evaluate the feasibility of high-resolution T2 mapping using a single-shot fast spin-echo (SS-FSE) sequence at 0.55~T in a healthy control cohort. \textbf{Study Type:} Prospective single-center study. \textbf{Population:} In vivo: ten healthy adults (18--43~years, 5 females/5 males). In vitro: NIST Phantom. \textbf{Field strength/sequence:} Multi-echo ultra-fast spin-echo at 0.55~T and 1.5~T. \textbf{Assessment:} Feasibility was first assessed in vitro using the NIST Phantom, comparing T2 relaxation times to spectrometer references at 0.55~T. Acquisition and T2-fitting parameters optimized in vitro were applied in vivo. Repeatability was evaluated by atlas-based analysis of white matter (WM) and cortical grey matter (GM) regions. Coefficients of variation (CoV) were computed across runs, sessions, and subjects. \textbf{Statistical Tests:} Wilcoxon signed-rank test with Bonferroni correction ($α= 0.05/n_{ROI}$) assessed CoV differences. Pearson correlation coefficients quantified T2 associations. \textbf{Results:} In vitro, mono-exponential fitting under Gaussian--Rician noise yielded deviations $<12\%$ from reference values. In vivo, inter-subject CoV was 5.2\% (WM) and 17.7\% (GM), comparable to 1.5~T. Mean T2 times were 118~ms (WM) and 188~ms (GM) at 0.55~T, with a 16.5-minute acquisition. \textbf{Conclusion:} A rapid, robust high-resolution T2 mapping protocol at 0.55~T for HASTE MRI is presented, employing Gaussian noise-based fitting. We report the first normative T2 values for healthy adult brains at 0.55~T, demonstrating technical feasibility and reliability. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2510_19680 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | T2 mapping at 0.55 T using Ultra-Fast Spin Echo MRI Roulet, Margaux Kebiri, Hamza Bulut, Busra Zalevskyi, Vladyslav Sanchez, Thomas Ledoux, Jean-Baptiste Dunet, Vincent Koob, Mériam Hilbert, Tom Kober, Tobias Canales-Rodriguez, Erick J Cuadra, Meritxell Bach Applied Physics Numerical Analysis Low-field T2 mapping MRI can democratize neuropediatric imaging by improving accessibility and providing quantitative biomarkers of brain development. \textbf{Purpose:} To evaluate the feasibility of high-resolution T2 mapping using a single-shot fast spin-echo (SS-FSE) sequence at 0.55~T in a healthy control cohort. \textbf{Study Type:} Prospective single-center study. \textbf{Population:} In vivo: ten healthy adults (18--43~years, 5 females/5 males). In vitro: NIST Phantom. \textbf{Field strength/sequence:} Multi-echo ultra-fast spin-echo at 0.55~T and 1.5~T. \textbf{Assessment:} Feasibility was first assessed in vitro using the NIST Phantom, comparing T2 relaxation times to spectrometer references at 0.55~T. Acquisition and T2-fitting parameters optimized in vitro were applied in vivo. Repeatability was evaluated by atlas-based analysis of white matter (WM) and cortical grey matter (GM) regions. Coefficients of variation (CoV) were computed across runs, sessions, and subjects. \textbf{Statistical Tests:} Wilcoxon signed-rank test with Bonferroni correction ($α= 0.05/n_{ROI}$) assessed CoV differences. Pearson correlation coefficients quantified T2 associations. \textbf{Results:} In vitro, mono-exponential fitting under Gaussian--Rician noise yielded deviations $<12\%$ from reference values. In vivo, inter-subject CoV was 5.2\% (WM) and 17.7\% (GM), comparable to 1.5~T. Mean T2 times were 118~ms (WM) and 188~ms (GM) at 0.55~T, with a 16.5-minute acquisition. \textbf{Conclusion:} A rapid, robust high-resolution T2 mapping protocol at 0.55~T for HASTE MRI is presented, employing Gaussian noise-based fitting. We report the first normative T2 values for healthy adult brains at 0.55~T, demonstrating technical feasibility and reliability. |
| title | T2 mapping at 0.55 T using Ultra-Fast Spin Echo MRI |
| topic | Applied Physics Numerical Analysis |
| url | https://arxiv.org/abs/2510.19680 |