Challenges and Recommendations in Establishing National Human Diversity Genomic Projects
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| Format: | Preprint |
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2025
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| author | Oleksyk, Taras K. Wolfsberger, Walter W. Chhugani, Karishma Huang, Yu-Ning Pokrytiuk, Valerii Shchubelka, Khrystyna Zelikovsky, Alex Pasaniuc, Bogdan Jinga, Viorel Bucur, Octavian Edmunds, Scott C. Guio, Heinner Lombard, Zane Henn, Brenna M. Lobiuc, Andrei Levitchi, Alexei Ciorba, Dumitru Bostan, Viorel Munteanu, Viorel Gordeev, Victor Schaaf, Christian P. Boon-Peng, Hoh Estrada, Andrés Moreno Covasa, Mihai Dimian, Mihai Kairov, Ulykbek Pak, Victoria M. Wee, Seow Shih Chiang, Charleston W. K. Nepolo, Emmanuel Pellegrini, Matteo Hamdi, Yosr Abedalthagafi, Malak S. Mulder, Nicola Jane Mooney, Jazlyn Sanchez-Galan, Javier E. de Souza, Sandro José Raventós, Henriette Muzzio, Marina Chavarria-Soley, Gabriela Mangul, Serghei |
| author_facet | Oleksyk, Taras K. Wolfsberger, Walter W. Chhugani, Karishma Huang, Yu-Ning Pokrytiuk, Valerii Shchubelka, Khrystyna Zelikovsky, Alex Pasaniuc, Bogdan Jinga, Viorel Bucur, Octavian Edmunds, Scott C. Guio, Heinner Lombard, Zane Henn, Brenna M. Lobiuc, Andrei Levitchi, Alexei Ciorba, Dumitru Bostan, Viorel Munteanu, Viorel Gordeev, Victor Schaaf, Christian P. Boon-Peng, Hoh Estrada, Andrés Moreno Covasa, Mihai Dimian, Mihai Kairov, Ulykbek Pak, Victoria M. Wee, Seow Shih Chiang, Charleston W. K. Nepolo, Emmanuel Pellegrini, Matteo Hamdi, Yosr Abedalthagafi, Malak S. Mulder, Nicola Jane Mooney, Jazlyn Sanchez-Galan, Javier E. de Souza, Sandro José Raventós, Henriette Muzzio, Marina Chavarria-Soley, Gabriela Mangul, Serghei |
| contents | Genomic approaches have revolutionized medical research, providing valuable insights into human physiology and disease. Despite major benefits from large collections of genomes, the lack of diversity in genomic data represents a significant challenge for advancing biomedical discovery and accessible health solutions worldwide. Establishing a national genomic project is not a one-size-fits-all endeavor, as each country presents distinct challenges and opportunities. We identify challenges in the way of obtaining and publishing data from Whole Genome Sequencing (WGS) of people in various countries, discuss the progress made by some in their efforts to study their genetic diversity, and assess the most common issues. We recognize that a successful national genome database requires addressing several major issues, including the variable awareness of the recent developments in genomics among government officials, healthcare administrators, and policymakers, the absence of regulations, and ethical considerations, the challenges in securing funding, establishing legal frameworks, and building the necessary infrastructure. By assembling a diverse team of experts across 19 countries, we aim to provide a balanced approach in our recommendations to establish national projects. Our study acknowledges and addresses major intricacies and nuances specific to various settings and regions while presenting diverse opinions of scientists from both high-resource and low-resource countries contributing to a more inclusive and globally relevant framework for advancing genomic research and its applications. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2510_19869 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | Challenges and Recommendations in Establishing National Human Diversity Genomic Projects Oleksyk, Taras K. Wolfsberger, Walter W. Chhugani, Karishma Huang, Yu-Ning Pokrytiuk, Valerii Shchubelka, Khrystyna Zelikovsky, Alex Pasaniuc, Bogdan Jinga, Viorel Bucur, Octavian Edmunds, Scott C. Guio, Heinner Lombard, Zane Henn, Brenna M. Lobiuc, Andrei Levitchi, Alexei Ciorba, Dumitru Bostan, Viorel Munteanu, Viorel Gordeev, Victor Schaaf, Christian P. Boon-Peng, Hoh Estrada, Andrés Moreno Covasa, Mihai Dimian, Mihai Kairov, Ulykbek Pak, Victoria M. Wee, Seow Shih Chiang, Charleston W. K. Nepolo, Emmanuel Pellegrini, Matteo Hamdi, Yosr Abedalthagafi, Malak S. Mulder, Nicola Jane Mooney, Jazlyn Sanchez-Galan, Javier E. de Souza, Sandro José Raventós, Henriette Muzzio, Marina Chavarria-Soley, Gabriela Mangul, Serghei Other Quantitative Biology Genomic approaches have revolutionized medical research, providing valuable insights into human physiology and disease. Despite major benefits from large collections of genomes, the lack of diversity in genomic data represents a significant challenge for advancing biomedical discovery and accessible health solutions worldwide. Establishing a national genomic project is not a one-size-fits-all endeavor, as each country presents distinct challenges and opportunities. We identify challenges in the way of obtaining and publishing data from Whole Genome Sequencing (WGS) of people in various countries, discuss the progress made by some in their efforts to study their genetic diversity, and assess the most common issues. We recognize that a successful national genome database requires addressing several major issues, including the variable awareness of the recent developments in genomics among government officials, healthcare administrators, and policymakers, the absence of regulations, and ethical considerations, the challenges in securing funding, establishing legal frameworks, and building the necessary infrastructure. By assembling a diverse team of experts across 19 countries, we aim to provide a balanced approach in our recommendations to establish national projects. Our study acknowledges and addresses major intricacies and nuances specific to various settings and regions while presenting diverse opinions of scientists from both high-resource and low-resource countries contributing to a more inclusive and globally relevant framework for advancing genomic research and its applications. |
| title | Challenges and Recommendations in Establishing National Human Diversity Genomic Projects |
| topic | Other Quantitative Biology |
| url | https://arxiv.org/abs/2510.19869 |