Light-sheet microscopy to assess cancer pathology: current views and future trends
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arXiv
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| Format: | Preprint |
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2025
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| author | Pisarović, Uma Ochi, Taichi Samarska, Iryna Silvestri, Ludovico van Nijnatten, Thiemo J. A. Kooreman, Loes F. S. Marcelissen, Tom Hausen, Axel zur Schueth, Anna |
| author_facet | Pisarović, Uma Ochi, Taichi Samarska, Iryna Silvestri, Ludovico van Nijnatten, Thiemo J. A. Kooreman, Loes F. S. Marcelissen, Tom Hausen, Axel zur Schueth, Anna |
| contents | In recent years, light-sheet fluorescence microscopy (LSFM) has emerged as a powerful tool for visualizing and analyzing cancer tissue samples, including patient-derived specimens, organoids, biopsies, and murine models. In this work, we highlight the current applications of deep tissue LSFM in oncology and illustrate its use across a variety of human cancer tissues, including - but not limited to - prostate and breast. Here, we discuss that the potential integration of advanced LSFM technologies into clinical workflows to enable high-throughput, three-dimensional imaging of intact cancer specimens. This approach holds significant potential to enhance diagnostic precision and provide novel insights into tumour architecture and morphology. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2510_21260 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | Light-sheet microscopy to assess cancer pathology: current views and future trends Pisarović, Uma Ochi, Taichi Samarska, Iryna Silvestri, Ludovico van Nijnatten, Thiemo J. A. Kooreman, Loes F. S. Marcelissen, Tom Hausen, Axel zur Schueth, Anna Medical Physics Optics In recent years, light-sheet fluorescence microscopy (LSFM) has emerged as a powerful tool for visualizing and analyzing cancer tissue samples, including patient-derived specimens, organoids, biopsies, and murine models. In this work, we highlight the current applications of deep tissue LSFM in oncology and illustrate its use across a variety of human cancer tissues, including - but not limited to - prostate and breast. Here, we discuss that the potential integration of advanced LSFM technologies into clinical workflows to enable high-throughput, three-dimensional imaging of intact cancer specimens. This approach holds significant potential to enhance diagnostic precision and provide novel insights into tumour architecture and morphology. |
| title | Light-sheet microscopy to assess cancer pathology: current views and future trends |
| topic | Medical Physics Optics |
| url | https://arxiv.org/abs/2510.21260 |