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| Main Authors: | , , , |
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| Format: | Preprint |
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2025
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| Subjects: | |
| Online Access: | https://arxiv.org/abs/2510.21281 |
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| _version_ | 1866918169436749824 |
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| author | Salomonsen, Christian Wickstrøm, Kristoffer K. Kuttner, Samuel Wetzer, Elisabeth |
| author_facet | Salomonsen, Christian Wickstrøm, Kristoffer K. Kuttner, Samuel Wetzer, Elisabeth |
| contents | Kinetic modeling enables \textit{in vivo} quantification of tracer uptake and glucose metabolism in [${}^{18}$F]Fluorodeoxyglucose ([${}^{18}$F]FDG) dynamic positron emission tomography (dPET) imaging of mice. However, kinetic modeling requires the accurate determination of the arterial input function (AIF) during imaging, which is time-consuming and invasive. Recent studies have shown the efficacy of using deep learning to directly predict the input function, surpassing established methods such as the image-derived input function (IDIF). In this work, we trained a physics-informed deep learning-based input function prediction model (PIDLIF) to estimate the AIF directly from the PET images, incorporating a kinetic modeling loss during training. The proposed method uses a two-tissue compartment model over two regions, the myocardium and brain of the mice, and is trained on a dataset of 70 [${}^{18}$F]FDG dPET images of mice accompanied by the measured AIF during imaging. The proposed method had comparable performance to the network without a physics-informed loss, and when sudden movement causing blurring in the images was simulated, the PIDLIF model maintained high performance in severe cases of image degradation. The proposed physics-informed method exhibits an improved robustness that is promoted by physically constraining the problem, enforcing consistency for out-of-distribution samples. In conclusion, the PIDLIF model offers insight into the effects of leveraging physiological distribution mechanics in mice to guide a deep learning-based AIF prediction network in images with severe degradation as a result of blurring due to movement during imaging. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2510_21281 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | Physics-Informed Deep Learning for Improved Input Function Estimation in Motion-Blurred Dynamic [${}^{18}$F]FDG PET Images Salomonsen, Christian Wickstrøm, Kristoffer K. Kuttner, Samuel Wetzer, Elisabeth Quantitative Methods Computer Vision and Pattern Recognition Kinetic modeling enables \textit{in vivo} quantification of tracer uptake and glucose metabolism in [${}^{18}$F]Fluorodeoxyglucose ([${}^{18}$F]FDG) dynamic positron emission tomography (dPET) imaging of mice. However, kinetic modeling requires the accurate determination of the arterial input function (AIF) during imaging, which is time-consuming and invasive. Recent studies have shown the efficacy of using deep learning to directly predict the input function, surpassing established methods such as the image-derived input function (IDIF). In this work, we trained a physics-informed deep learning-based input function prediction model (PIDLIF) to estimate the AIF directly from the PET images, incorporating a kinetic modeling loss during training. The proposed method uses a two-tissue compartment model over two regions, the myocardium and brain of the mice, and is trained on a dataset of 70 [${}^{18}$F]FDG dPET images of mice accompanied by the measured AIF during imaging. The proposed method had comparable performance to the network without a physics-informed loss, and when sudden movement causing blurring in the images was simulated, the PIDLIF model maintained high performance in severe cases of image degradation. The proposed physics-informed method exhibits an improved robustness that is promoted by physically constraining the problem, enforcing consistency for out-of-distribution samples. In conclusion, the PIDLIF model offers insight into the effects of leveraging physiological distribution mechanics in mice to guide a deep learning-based AIF prediction network in images with severe degradation as a result of blurring due to movement during imaging. |
| title | Physics-Informed Deep Learning for Improved Input Function Estimation in Motion-Blurred Dynamic [${}^{18}$F]FDG PET Images |
| topic | Quantitative Methods Computer Vision and Pattern Recognition |
| url | https://arxiv.org/abs/2510.21281 |