Mastering energy landscapes via liquid liquid phase separation to program active supramolecular coassembly from the nano to macro scale
Fuente:
arXiv
Gespeichert in:
| Hauptverfasser: | , , , , , , , , |
|---|---|
| Format: | Preprint |
| Veröffentlicht: |
2025
|
| Schlagworte: | |
| Online-Zugang: | |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| _version_ | 1866911234376335360 |
|---|---|
| author | Wu, Yuanhao van Teijlingen, Alexander Watts, Julie Yu, Zhiquan Su, Shanshan RodriguezCabello, Jose Carlos Abramovich, Lihi Tuttle, Tell Mata, Alvaro |
| author_facet | Wu, Yuanhao van Teijlingen, Alexander Watts, Julie Yu, Zhiquan Su, Shanshan RodriguezCabello, Jose Carlos Abramovich, Lihi Tuttle, Tell Mata, Alvaro |
| contents | The energy landscape dictates pathways and outcomes in supramolecular selfassembly, yet harnessing it from the nano to the macro scales remains a major challenge. Here, we demonstrate liquid liquid phase separation (LLPS) as a powerful tool to navigate and engineer the energy landscapes of coassembly systems comprising disordered proteins and peptides. We quantitatively map the energy barriers and transition states governing structural transitions, enabling predictive on off control of assembly and hierarchical order from nano to macro scales. By integrating supramolecular biofabrication, we achieve spatially organized architectures with life like non equilibrium behaviour. Crucially, assembly stability and scalable selfsorting are shown to depend on accessing minimum energy states, regardless of whether the co assembled structures are disordered or ordered. This work establishes energy landscape mediation via LLPS as a general framework for designing lifelike, hierarchically structured materials. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2510_23017 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | Mastering energy landscapes via liquid liquid phase separation to program active supramolecular coassembly from the nano to macro scale Wu, Yuanhao van Teijlingen, Alexander Watts, Julie Yu, Zhiquan Su, Shanshan RodriguezCabello, Jose Carlos Abramovich, Lihi Tuttle, Tell Mata, Alvaro Soft Condensed Matter Materials Science Chemical Physics The energy landscape dictates pathways and outcomes in supramolecular selfassembly, yet harnessing it from the nano to the macro scales remains a major challenge. Here, we demonstrate liquid liquid phase separation (LLPS) as a powerful tool to navigate and engineer the energy landscapes of coassembly systems comprising disordered proteins and peptides. We quantitatively map the energy barriers and transition states governing structural transitions, enabling predictive on off control of assembly and hierarchical order from nano to macro scales. By integrating supramolecular biofabrication, we achieve spatially organized architectures with life like non equilibrium behaviour. Crucially, assembly stability and scalable selfsorting are shown to depend on accessing minimum energy states, regardless of whether the co assembled structures are disordered or ordered. This work establishes energy landscape mediation via LLPS as a general framework for designing lifelike, hierarchically structured materials. |
| title | Mastering energy landscapes via liquid liquid phase separation to program active supramolecular coassembly from the nano to macro scale |
| topic | Soft Condensed Matter Materials Science Chemical Physics |
| url | https://arxiv.org/abs/2510.23017 |