ME-FIRST: A Metasurface-Enhanced Fingerprint InfraRed Spectroscopic Tool for Fluid Analytes
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| Format: | Preprint |
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2025
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| _version_ | 1866908754486755328 |
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| author | Zhao, Xiangyu Liu, Yuqing Shao, Jingzhu Fang, Longsheng Wu, Chongzhao |
| author_facet | Zhao, Xiangyu Liu, Yuqing Shao, Jingzhu Fang, Longsheng Wu, Chongzhao |
| contents | Infrared (IR) spectroscopy has emerged as a pivotal tool in biomedical diagnostics, offering label-free spectral biomarkers for the detection of numerous diseases, particularly in the fingerprint region. However, the lack of rapid and sensitive IR spectroscopic techniques for analyzing complex fluid analytes remains a critical challenge in clinical practice. To address this limitation, we present a Metasurface-Enhanced Fingerprint InfraRed Spectroscopic Tool (ME-FIRST) that enhances light-matter interactions in sub-wavelength volumes through plasmonic resonances across the entire fingerprint range from $1900 cm^{-1}$ to $1000 cm^{-1}$. Numerical simulations reveal confined and enhanced electric near-field, with an average probing depth of ~100 nm and enhancement factor $|E/E_0|$ of ~60-fold at resonant peaks. The ME-FIRST device is further experimentally fabricated and validated, and as a proof of concept, we demonstrate the sensing of molecular vibrational modes with a considerable sensitivity in L-lysine over the full fingerprint IR spectral range. The proposed ME-FIRST presents a promising platform for high-sensitivity IR spectroscopy of fluid analytes, paving the way for clinical applications of infrared spectroscopy in biofluid analysis and pathological scenarios. |
| format | Preprint |
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arxiv_https___arxiv_org_abs_2510_24210 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | ME-FIRST: A Metasurface-Enhanced Fingerprint InfraRed Spectroscopic Tool for Fluid Analytes Zhao, Xiangyu Liu, Yuqing Shao, Jingzhu Fang, Longsheng Wu, Chongzhao Optics Applied Physics Infrared (IR) spectroscopy has emerged as a pivotal tool in biomedical diagnostics, offering label-free spectral biomarkers for the detection of numerous diseases, particularly in the fingerprint region. However, the lack of rapid and sensitive IR spectroscopic techniques for analyzing complex fluid analytes remains a critical challenge in clinical practice. To address this limitation, we present a Metasurface-Enhanced Fingerprint InfraRed Spectroscopic Tool (ME-FIRST) that enhances light-matter interactions in sub-wavelength volumes through plasmonic resonances across the entire fingerprint range from $1900 cm^{-1}$ to $1000 cm^{-1}$. Numerical simulations reveal confined and enhanced electric near-field, with an average probing depth of ~100 nm and enhancement factor $|E/E_0|$ of ~60-fold at resonant peaks. The ME-FIRST device is further experimentally fabricated and validated, and as a proof of concept, we demonstrate the sensing of molecular vibrational modes with a considerable sensitivity in L-lysine over the full fingerprint IR spectral range. The proposed ME-FIRST presents a promising platform for high-sensitivity IR spectroscopy of fluid analytes, paving the way for clinical applications of infrared spectroscopy in biofluid analysis and pathological scenarios. |
| title | ME-FIRST: A Metasurface-Enhanced Fingerprint InfraRed Spectroscopic Tool for Fluid Analytes |
| topic | Optics Applied Physics |
| url | https://arxiv.org/abs/2510.24210 |