SciTrust 2.0: A Comprehensive Framework for Evaluating Trustworthiness of Large Language Models in Scientific Applications

Fuente: arXiv
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Autori principali: Herron, Emily, Yin, Junqi, Wang, Feiyi
Natura: Preprint
Pubblicazione: 2025
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author Herron, Emily
Yin, Junqi
Wang, Feiyi
author_facet Herron, Emily
Yin, Junqi
Wang, Feiyi
contents Large language models (LLMs) have demonstrated transformative potential in scientific research, yet their deployment in high-stakes contexts raises significant trustworthiness concerns. Here, we introduce SciTrust 2.0, a comprehensive framework for evaluating LLM trustworthiness in scientific applications across four dimensions: truthfulness, adversarial robustness, scientific safety, and scientific ethics. Our framework incorporates novel, open-ended truthfulness benchmarks developed through a verified reflection-tuning pipeline and expert validation, alongside a novel ethics benchmark for scientific research contexts covering eight subcategories including dual-use research and bias. We evaluated seven prominent LLMs, including four science-specialized models and three general-purpose industry models, using multiple evaluation metrics including accuracy, semantic similarity measures, and LLM-based scoring. General-purpose industry models overall outperformed science-specialized models across each trustworthiness dimension, with GPT-o4-mini demonstrating superior performance in truthfulness assessments and adversarial robustness. Science-specialized models showed significant deficiencies in logical and ethical reasoning capabilities, along with concerning vulnerabilities in safety evaluations, particularly in high-risk domains such as biosecurity and chemical weapons. By open-sourcing our framework, we provide a foundation for developing more trustworthy AI systems and advancing research on model safety and ethics in scientific contexts.
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id arxiv_https___arxiv_org_abs_2510_25908
institution arXiv
publishDate 2025
record_format arxiv
spellingShingle SciTrust 2.0: A Comprehensive Framework for Evaluating Trustworthiness of Large Language Models in Scientific Applications
Herron, Emily
Yin, Junqi
Wang, Feiyi
Artificial Intelligence
Large language models (LLMs) have demonstrated transformative potential in scientific research, yet their deployment in high-stakes contexts raises significant trustworthiness concerns. Here, we introduce SciTrust 2.0, a comprehensive framework for evaluating LLM trustworthiness in scientific applications across four dimensions: truthfulness, adversarial robustness, scientific safety, and scientific ethics. Our framework incorporates novel, open-ended truthfulness benchmarks developed through a verified reflection-tuning pipeline and expert validation, alongside a novel ethics benchmark for scientific research contexts covering eight subcategories including dual-use research and bias. We evaluated seven prominent LLMs, including four science-specialized models and three general-purpose industry models, using multiple evaluation metrics including accuracy, semantic similarity measures, and LLM-based scoring. General-purpose industry models overall outperformed science-specialized models across each trustworthiness dimension, with GPT-o4-mini demonstrating superior performance in truthfulness assessments and adversarial robustness. Science-specialized models showed significant deficiencies in logical and ethical reasoning capabilities, along with concerning vulnerabilities in safety evaluations, particularly in high-risk domains such as biosecurity and chemical weapons. By open-sourcing our framework, we provide a foundation for developing more trustworthy AI systems and advancing research on model safety and ethics in scientific contexts.
title SciTrust 2.0: A Comprehensive Framework for Evaluating Trustworthiness of Large Language Models in Scientific Applications
topic Artificial Intelligence
url https://arxiv.org/abs/2510.25908