Broadly tunable quantum-enhanced Raman microscopy for advancing bioimaging
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arXiv
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| Main Authors: | , , , , , |
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| Format: | Preprint |
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2025
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| _version_ | 1866911503778578432 |
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| author | Akatev, Dmitrii Meng, Yijian Brewer, Jonathan Chekhova, Maria Andersen, Ulrik L. Lassen, Mikael |
| author_facet | Akatev, Dmitrii Meng, Yijian Brewer, Jonathan Chekhova, Maria Andersen, Ulrik L. Lassen, Mikael |
| contents | Stimulated Raman scattering (SRS) microscopy has emerged as a powerful technique for probing the spatiotemporal dynamics of molecular bonds with exceptional sensitivity, resolution, and speed. However, classically, its performance remains fundamentally constrained by optical shot noise, which imposes a strict limit on detection sensitivity and speed. Here, we demonstrate a quantum-enhanced SRS microscopy platform that circumvents this barrier by harnessing amplitude-squeezed light. Specifically, we generate a Stokes beam with $5.2~\mathrm{dB}$ of amplitude squeezing using traveling-wave optical parametric amplification in second-order nonlinear waveguides, and combine it with a tunable coherent pump to access vibrational modes spanning from $1000$ to $3100~\mathrm{cm}^{-1}$. Applied to quantum imaging of metabolites in biological tissue (pork muscle), our quantum-enhanced Raman microscope achieves an average noise suppression of $3.6~\mathrm{dB}$ and a $51\%$ enhancement in signal-to-noise ratio (SNR) -- to the best of our knowledge, the largest improvement reported to date in quantum-enhanced SRS microscopy of biological samples. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2511_01430 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | Broadly tunable quantum-enhanced Raman microscopy for advancing bioimaging Akatev, Dmitrii Meng, Yijian Brewer, Jonathan Chekhova, Maria Andersen, Ulrik L. Lassen, Mikael Optics Quantum Physics Stimulated Raman scattering (SRS) microscopy has emerged as a powerful technique for probing the spatiotemporal dynamics of molecular bonds with exceptional sensitivity, resolution, and speed. However, classically, its performance remains fundamentally constrained by optical shot noise, which imposes a strict limit on detection sensitivity and speed. Here, we demonstrate a quantum-enhanced SRS microscopy platform that circumvents this barrier by harnessing amplitude-squeezed light. Specifically, we generate a Stokes beam with $5.2~\mathrm{dB}$ of amplitude squeezing using traveling-wave optical parametric amplification in second-order nonlinear waveguides, and combine it with a tunable coherent pump to access vibrational modes spanning from $1000$ to $3100~\mathrm{cm}^{-1}$. Applied to quantum imaging of metabolites in biological tissue (pork muscle), our quantum-enhanced Raman microscope achieves an average noise suppression of $3.6~\mathrm{dB}$ and a $51\%$ enhancement in signal-to-noise ratio (SNR) -- to the best of our knowledge, the largest improvement reported to date in quantum-enhanced SRS microscopy of biological samples. |
| title | Broadly tunable quantum-enhanced Raman microscopy for advancing bioimaging |
| topic | Optics Quantum Physics |
| url | https://arxiv.org/abs/2511.01430 |