Understanding Cross Task Generalization in Handwriting-Based Alzheimer's Screening via Vision Language Adaptation
Fuente:
arXiv
Salvato in:
| Autori principali: | , , |
|---|---|
| Natura: | Preprint |
| Pubblicazione: |
2025
|
| Soggetti: | |
| Accesso online: | |
| Tags: |
Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne!!
|
| _version_ | 1866908638452383744 |
|---|---|
| author | Gong, Changqing Qin, Huafeng El-Yacoubi, Mounim A. |
| author_facet | Gong, Changqing Qin, Huafeng El-Yacoubi, Mounim A. |
| contents | Alzheimer's disease is a prevalent neurodegenerative disorder for which early detection is critical. Handwriting-often disrupted in prodromal AD-provides a non-invasive and cost-effective window into subtle motor and cognitive decline. Existing handwriting-based AD studies, mostly relying on online trajectories and hand-crafted features, have not systematically examined how task type influences diagnostic performance and cross-task generalization. Meanwhile, large-scale vision language models have demonstrated remarkable zero or few-shot anomaly detection in natural images and strong adaptability across medical modalities such as chest X-ray and brain MRI. However, handwriting-based disease detection remains largely unexplored within this paradigm. To close this gap, we introduce a lightweight Cross-Layer Fusion Adapter framework that repurposes CLIP for handwriting-based AD screening. CLFA implants multi-level fusion adapters within the visual encoder to progressively align representations toward handwriting-specific medical cues, enabling prompt-free and efficient zero-shot inference. Using this framework, we systematically investigate cross-task generalization-training on a specific handwriting task and evaluating on unseen ones-to reveal which task types and writing patterns most effectively discriminate AD. Extensive analyses further highlight characteristic stroke patterns and task-level factors that contribute to early AD identification, offering both diagnostic insights and a benchmark for handwriting-based cognitive assessment. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2511_05841 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | Understanding Cross Task Generalization in Handwriting-Based Alzheimer's Screening via Vision Language Adaptation Gong, Changqing Qin, Huafeng El-Yacoubi, Mounim A. Computer Vision and Pattern Recognition Artificial Intelligence Alzheimer's disease is a prevalent neurodegenerative disorder for which early detection is critical. Handwriting-often disrupted in prodromal AD-provides a non-invasive and cost-effective window into subtle motor and cognitive decline. Existing handwriting-based AD studies, mostly relying on online trajectories and hand-crafted features, have not systematically examined how task type influences diagnostic performance and cross-task generalization. Meanwhile, large-scale vision language models have demonstrated remarkable zero or few-shot anomaly detection in natural images and strong adaptability across medical modalities such as chest X-ray and brain MRI. However, handwriting-based disease detection remains largely unexplored within this paradigm. To close this gap, we introduce a lightweight Cross-Layer Fusion Adapter framework that repurposes CLIP for handwriting-based AD screening. CLFA implants multi-level fusion adapters within the visual encoder to progressively align representations toward handwriting-specific medical cues, enabling prompt-free and efficient zero-shot inference. Using this framework, we systematically investigate cross-task generalization-training on a specific handwriting task and evaluating on unseen ones-to reveal which task types and writing patterns most effectively discriminate AD. Extensive analyses further highlight characteristic stroke patterns and task-level factors that contribute to early AD identification, offering both diagnostic insights and a benchmark for handwriting-based cognitive assessment. |
| title | Understanding Cross Task Generalization in Handwriting-Based Alzheimer's Screening via Vision Language Adaptation |
| topic | Computer Vision and Pattern Recognition Artificial Intelligence |
| url | https://arxiv.org/abs/2511.05841 |