Dynamics of chemo-receptor activity with time-periodic attractant field
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arXiv
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| Natura: | Preprint |
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2025
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| _version_ | 1866915611823570944 |
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| author | Pramanik, Ramesh Yadav, Ramu K Chatterjee, Sakuntala |
| author_facet | Pramanik, Ramesh Yadav, Ramu K Chatterjee, Sakuntala |
| contents | When exposed to a time-periodic chemical signal, an \textit{E.~coli} cell responds by modulating its receptor activity in a similar time-periodic manner. However, there exists a phase lag between the applied signal and the activity response. We study the variation of the activity amplitude and phase lag as a function of the applied frequency~$ω$, using numerical simulations. The amplitude increases with~$ω$, reaches a plateau, and then decreases again for large~$ω$. The phase lag increases monotonically with~$ω$ and finally saturates to $3π/2$ when~$ω$ is large. The activity is no longer a single-valued function of the attractant signal, and plotting activity versus attractant concentration over one complete time period generates a loop. We monitor the loop area as a function of~$ω$ and find two peaks for small and large~$ω$, and a sharp minimum at intermediate~$ω$ values. We explain these results as an interplay between the time scales associated with adaptation, activity switching, and applied signal variation. In particular, for very large~$ω$, the quasi-equilibrium approximation for activity dynamics breaks down, a regime that has not been explored in earlier studies. We perform analytical calculations in this limit and find good agreement with our simulation results. |
| format | Preprint |
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arxiv_https___arxiv_org_abs_2511_07868 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | Dynamics of chemo-receptor activity with time-periodic attractant field Pramanik, Ramesh Yadav, Ramu K Chatterjee, Sakuntala Biological Physics 92C17, 37N25, 34C60, 92C05 When exposed to a time-periodic chemical signal, an \textit{E.~coli} cell responds by modulating its receptor activity in a similar time-periodic manner. However, there exists a phase lag between the applied signal and the activity response. We study the variation of the activity amplitude and phase lag as a function of the applied frequency~$ω$, using numerical simulations. The amplitude increases with~$ω$, reaches a plateau, and then decreases again for large~$ω$. The phase lag increases monotonically with~$ω$ and finally saturates to $3π/2$ when~$ω$ is large. The activity is no longer a single-valued function of the attractant signal, and plotting activity versus attractant concentration over one complete time period generates a loop. We monitor the loop area as a function of~$ω$ and find two peaks for small and large~$ω$, and a sharp minimum at intermediate~$ω$ values. We explain these results as an interplay between the time scales associated with adaptation, activity switching, and applied signal variation. In particular, for very large~$ω$, the quasi-equilibrium approximation for activity dynamics breaks down, a regime that has not been explored in earlier studies. We perform analytical calculations in this limit and find good agreement with our simulation results. |
| title | Dynamics of chemo-receptor activity with time-periodic attractant field |
| topic | Biological Physics 92C17, 37N25, 34C60, 92C05 |
| url | https://arxiv.org/abs/2511.07868 |