From Retinal Pixels to Patients: Evolution of Deep Learning Research in Diabetic Retinopathy Screening

Fuente: arXiv
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Hauptverfasser: Chopra, Muskaan, Sparrenberg, Lorenz, Berger, Armin, Khanna, Sarthak, Terheyden, Jan H., Sifa, Rafet
Format: Preprint
Veröffentlicht: 2025
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author Chopra, Muskaan
Sparrenberg, Lorenz
Berger, Armin
Khanna, Sarthak
Terheyden, Jan H.
Sifa, Rafet
author_facet Chopra, Muskaan
Sparrenberg, Lorenz
Berger, Armin
Khanna, Sarthak
Terheyden, Jan H.
Sifa, Rafet
contents Diabetic Retinopathy (DR) remains a leading cause of preventable blindness, with early detection critical for reducing vision loss worldwide. Over the past decade, deep learning has transformed DR screening, progressing from early convolutional neural networks trained on private datasets to advanced pipelines addressing class imbalance, label scarcity, domain shift, and interpretability. This survey provides the first systematic synthesis of DR research spanning 2016-2025, consolidating results from 50+ studies and over 20 datasets. We critically examine methodological advances, including self- and semi-supervised learning, domain generalization, federated training, and hybrid neuro-symbolic models, alongside evaluation protocols, reporting standards, and reproducibility challenges. Benchmark tables contextualize performance across datasets, while discussion highlights open gaps in multi-center validation and clinical trust. By linking technical progress with translational barriers, this work outlines a practical agenda for reproducible, privacy-preserving, and clinically deployable DR AI. Beyond DR, many of the surveyed innovations extend broadly to medical imaging at scale.
format Preprint
id arxiv_https___arxiv_org_abs_2511_11065
institution arXiv
publishDate 2025
record_format arxiv
spellingShingle From Retinal Pixels to Patients: Evolution of Deep Learning Research in Diabetic Retinopathy Screening
Chopra, Muskaan
Sparrenberg, Lorenz
Berger, Armin
Khanna, Sarthak
Terheyden, Jan H.
Sifa, Rafet
Computer Vision and Pattern Recognition
Artificial Intelligence
Diabetic Retinopathy (DR) remains a leading cause of preventable blindness, with early detection critical for reducing vision loss worldwide. Over the past decade, deep learning has transformed DR screening, progressing from early convolutional neural networks trained on private datasets to advanced pipelines addressing class imbalance, label scarcity, domain shift, and interpretability. This survey provides the first systematic synthesis of DR research spanning 2016-2025, consolidating results from 50+ studies and over 20 datasets. We critically examine methodological advances, including self- and semi-supervised learning, domain generalization, federated training, and hybrid neuro-symbolic models, alongside evaluation protocols, reporting standards, and reproducibility challenges. Benchmark tables contextualize performance across datasets, while discussion highlights open gaps in multi-center validation and clinical trust. By linking technical progress with translational barriers, this work outlines a practical agenda for reproducible, privacy-preserving, and clinically deployable DR AI. Beyond DR, many of the surveyed innovations extend broadly to medical imaging at scale.
title From Retinal Pixels to Patients: Evolution of Deep Learning Research in Diabetic Retinopathy Screening
topic Computer Vision and Pattern Recognition
Artificial Intelligence
url https://arxiv.org/abs/2511.11065