FaNe: Towards Fine-Grained Cross-Modal Contrast with False-Negative Reduction and Text-Conditioned Sparse Attention

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Main Authors: Zhang, Peng, Lai, Zhihui, Chen, Wenting, Wu, Xu, Kong, Heng
Format: Preprint
Published: 2025
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author Zhang, Peng
Lai, Zhihui
Chen, Wenting
Wu, Xu
Kong, Heng
author_facet Zhang, Peng
Lai, Zhihui
Chen, Wenting
Wu, Xu
Kong, Heng
contents Medical vision-language pre-training (VLP) offers significant potential for advancing medical image understanding by leveraging paired image-report data. However, existing methods are limited by Fa}lse Negatives (FaNe) induced by semantically similar texts and insufficient fine-grained cross-modal alignment. To address these limitations, we propose FaNe, a semantic-enhanced VLP framework. To mitigate false negatives, we introduce a semantic-aware positive pair mining strategy based on text-text similarity with adaptive normalization. Furthermore, we design a text-conditioned sparse attention pooling module to enable fine-grained image-text alignment through localized visual representations guided by textual cues. To strengthen intra-modal discrimination, we develop a hard-negative aware contrastive loss that adaptively reweights semantically similar negatives. Extensive experiments on five downstream medical imaging benchmarks demonstrate that FaNe achieves state-of-the-art performance across image classification, object detection, and semantic segmentation, validating the effectiveness of our framework.
format Preprint
id arxiv_https___arxiv_org_abs_2511_12215
institution arXiv
publishDate 2025
record_format arxiv
spellingShingle FaNe: Towards Fine-Grained Cross-Modal Contrast with False-Negative Reduction and Text-Conditioned Sparse Attention
Zhang, Peng
Lai, Zhihui
Chen, Wenting
Wu, Xu
Kong, Heng
Computer Vision and Pattern Recognition
Medical vision-language pre-training (VLP) offers significant potential for advancing medical image understanding by leveraging paired image-report data. However, existing methods are limited by Fa}lse Negatives (FaNe) induced by semantically similar texts and insufficient fine-grained cross-modal alignment. To address these limitations, we propose FaNe, a semantic-enhanced VLP framework. To mitigate false negatives, we introduce a semantic-aware positive pair mining strategy based on text-text similarity with adaptive normalization. Furthermore, we design a text-conditioned sparse attention pooling module to enable fine-grained image-text alignment through localized visual representations guided by textual cues. To strengthen intra-modal discrimination, we develop a hard-negative aware contrastive loss that adaptively reweights semantically similar negatives. Extensive experiments on five downstream medical imaging benchmarks demonstrate that FaNe achieves state-of-the-art performance across image classification, object detection, and semantic segmentation, validating the effectiveness of our framework.
title FaNe: Towards Fine-Grained Cross-Modal Contrast with False-Negative Reduction and Text-Conditioned Sparse Attention
topic Computer Vision and Pattern Recognition
url https://arxiv.org/abs/2511.12215