Effect of Dopamine in Enhancement of SNR of Cortico-Striatal-Thalamo-Cortical Loop Spiking
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| Main Authors: | , , |
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| Format: | Preprint |
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2025
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| _version_ | 1866912728816287744 |
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| author | Barati, Hadi Nayerifar, Ali Fardmanesh, Mehdi |
| author_facet | Barati, Hadi Nayerifar, Ali Fardmanesh, Mehdi |
| contents | In this work, the effects of dopamine neurotransmitter within the Cortico-Striatal-Thalamo-Cortical (CSTC) loop have been investigated. Simulations confirmed dopamine facilitates movement via thalamic disinhibition. Analysis of its impact on the signal-to-noise ratio (SNR) revealed a complex, region-specific outcome: SNR increased in some regions (e.g., D2 Striatum: 3.41 dB to 6.25 dB), decreased in others (e.g., Thalamus VL: 6.24 dB to 3.93 dB), and remained stable elsewhere (e.g., M1: 3.16 dB to 3.13 dB). This heterogeneity stems from dopamine increasing the excitability of D1-receptor-expressing neurons, which amplifies channel conductance noise and reduces SNR in specific circuits. Thus, dopamine acts not as a uniform signal enhancer, but as a complex modulator that critically balances facilitation and noise within the CSTC loop. |
| format | Preprint |
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arxiv_https___arxiv_org_abs_2511_14466 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | Effect of Dopamine in Enhancement of SNR of Cortico-Striatal-Thalamo-Cortical Loop Spiking Barati, Hadi Nayerifar, Ali Fardmanesh, Mehdi Neurons and Cognition In this work, the effects of dopamine neurotransmitter within the Cortico-Striatal-Thalamo-Cortical (CSTC) loop have been investigated. Simulations confirmed dopamine facilitates movement via thalamic disinhibition. Analysis of its impact on the signal-to-noise ratio (SNR) revealed a complex, region-specific outcome: SNR increased in some regions (e.g., D2 Striatum: 3.41 dB to 6.25 dB), decreased in others (e.g., Thalamus VL: 6.24 dB to 3.93 dB), and remained stable elsewhere (e.g., M1: 3.16 dB to 3.13 dB). This heterogeneity stems from dopamine increasing the excitability of D1-receptor-expressing neurons, which amplifies channel conductance noise and reduces SNR in specific circuits. Thus, dopamine acts not as a uniform signal enhancer, but as a complex modulator that critically balances facilitation and noise within the CSTC loop. |
| title | Effect of Dopamine in Enhancement of SNR of Cortico-Striatal-Thalamo-Cortical Loop Spiking |
| topic | Neurons and Cognition |
| url | https://arxiv.org/abs/2511.14466 |