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| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Preprint |
| Published: |
2025
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| Subjects: | |
| Online Access: | https://arxiv.org/abs/2511.21344 |
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| _version_ | 1866917106507841536 |
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| author | Werner, Julius Pennazio, Francesco Cerello, Piergiorgio Fiorina, Elisa Giordanengo, Simona Milian, Felix Mas Mereghetti, Alessio Mostardi, Franco Pullia, Marco Ranjbar, Sahar Sacchi, Roberto Vignati, Anna Rafecas, Magdalena Ferrero, Veronica |
| author_facet | Werner, Julius Pennazio, Francesco Cerello, Piergiorgio Fiorina, Elisa Giordanengo, Simona Milian, Felix Mas Mereghetti, Alessio Mostardi, Franco Pullia, Marco Ranjbar, Sahar Sacchi, Roberto Vignati, Anna Rafecas, Magdalena Ferrero, Veronica |
| contents | Proton therapy's full potential is limited by uncertainties that prevent optimal dose distribution. Monitoring techniques can reduce these uncertainties and enable adaptive treatment planning. Spatiotemporal Emission Reconstruction from Prompt-Gamma Timing (SER-PGT) is a promising method that provides insights into both particle range and stopping power, whose calculation would normally require knowledge about patient tissue properties that cannot be directly measured. We present the first experimental results using a 226.9 MeV synchrotron-proton beam impinging on a homogeneous phantom at a sub-clinical intensity (2 - 4 x 10^7 pps). SER-PGT uses data from a multi-detector setup: a thin and segmented Low Gain Avalanche Diode for proton detection and Lanthanum Bromide-based crystals for photon detection. The estimated stopping power profile showed an 8% +- 3% average error compared to NIST PSTAR values, and 2% +- 2% deviation relative to water at 100 MeV. Range assessment in a phantom with a 4 cm air-gap successfully identified the range shift with a 3 mm standard deviation. These results demonstrate the feasibility of using SER-PGT to recover both range and stopping power information through particle kinematics and PGT measurements. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2511_21344 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | Stopping power monitoring during proton therapy by means of prompt gamma timing: first experimental results with a homogeneous phantom Werner, Julius Pennazio, Francesco Cerello, Piergiorgio Fiorina, Elisa Giordanengo, Simona Milian, Felix Mas Mereghetti, Alessio Mostardi, Franco Pullia, Marco Ranjbar, Sahar Sacchi, Roberto Vignati, Anna Rafecas, Magdalena Ferrero, Veronica Medical Physics Proton therapy's full potential is limited by uncertainties that prevent optimal dose distribution. Monitoring techniques can reduce these uncertainties and enable adaptive treatment planning. Spatiotemporal Emission Reconstruction from Prompt-Gamma Timing (SER-PGT) is a promising method that provides insights into both particle range and stopping power, whose calculation would normally require knowledge about patient tissue properties that cannot be directly measured. We present the first experimental results using a 226.9 MeV synchrotron-proton beam impinging on a homogeneous phantom at a sub-clinical intensity (2 - 4 x 10^7 pps). SER-PGT uses data from a multi-detector setup: a thin and segmented Low Gain Avalanche Diode for proton detection and Lanthanum Bromide-based crystals for photon detection. The estimated stopping power profile showed an 8% +- 3% average error compared to NIST PSTAR values, and 2% +- 2% deviation relative to water at 100 MeV. Range assessment in a phantom with a 4 cm air-gap successfully identified the range shift with a 3 mm standard deviation. These results demonstrate the feasibility of using SER-PGT to recover both range and stopping power information through particle kinematics and PGT measurements. |
| title | Stopping power monitoring during proton therapy by means of prompt gamma timing: first experimental results with a homogeneous phantom |
| topic | Medical Physics |
| url | https://arxiv.org/abs/2511.21344 |