Beyond Size and Growth: Rethinking Lung Cancer Screening with AI Based Nodule Detection and Diagnosis
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| Format: | Preprint |
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2025
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| _version_ | 1866917510676217856 |
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| author | Bodard, Sylvain Baudot, Pierre Renoust, Benjamin Voyton, Charles De Bie, Gwendoline Geremia, Ezequiel Le, Van-Khoa Francis, Danny Siot, Pierre-Henri Haddou, Yousra Bobin, Vincent Brisset, Jean-Christophe Thomson, Carey C. Bourdes, Valerie Huet, Benoit |
| author_facet | Bodard, Sylvain Baudot, Pierre Renoust, Benjamin Voyton, Charles De Bie, Gwendoline Geremia, Ezequiel Le, Van-Khoa Francis, Danny Siot, Pierre-Henri Haddou, Yousra Bobin, Vincent Brisset, Jean-Christophe Thomson, Carey C. Bourdes, Valerie Huet, Benoit |
| contents | Early detection of malignant lung nodules remains constrained by size and growth based screening criteria, often delaying diagnosis. We present an integrated AI system that jointly performs nodule detection and malignancy assessment directly at the nodule level from low dose CT scans, within a unified CADe/CADx framework. Unlike conventional pipelines separating detection and diagnosis, our approach targets malignant nodules directly, redefining evaluation at the point where clinical decisions are made.
To address limitations in dataset scale and explainability, the system consists of a Large Ensemble Model (LEM) combining ensembles of shallow deep learning and feature based models. It was trained and evaluated on 25,709 scans with 69,449 annotated nodules, with external validation on an independent cohort. It achieved an AUC of 0.98 internally and 0.945 externally, outperforming all growth based metrics, Lung RADS size based triage, European volume and VDT based screening criteria, radiologists, and leading AI models.
The model maintains high sensitivity at low false positive rates, excels for small and early stage cancers, and enables malignancy assessment up to one year earlier than radiologists for indeterminate and slow growing nodules. This approach has the potential to streamline lung cancer screening workflows and support earlier, more actionable clinical decision making. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2512_00281 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | Beyond Size and Growth: Rethinking Lung Cancer Screening with AI Based Nodule Detection and Diagnosis Bodard, Sylvain Baudot, Pierre Renoust, Benjamin Voyton, Charles De Bie, Gwendoline Geremia, Ezequiel Le, Van-Khoa Francis, Danny Siot, Pierre-Henri Haddou, Yousra Bobin, Vincent Brisset, Jean-Christophe Thomson, Carey C. Bourdes, Valerie Huet, Benoit Computer Vision and Pattern Recognition Neurons and Cognition 92-04 I.2.10; J.6; J.3 Early detection of malignant lung nodules remains constrained by size and growth based screening criteria, often delaying diagnosis. We present an integrated AI system that jointly performs nodule detection and malignancy assessment directly at the nodule level from low dose CT scans, within a unified CADe/CADx framework. Unlike conventional pipelines separating detection and diagnosis, our approach targets malignant nodules directly, redefining evaluation at the point where clinical decisions are made. To address limitations in dataset scale and explainability, the system consists of a Large Ensemble Model (LEM) combining ensembles of shallow deep learning and feature based models. It was trained and evaluated on 25,709 scans with 69,449 annotated nodules, with external validation on an independent cohort. It achieved an AUC of 0.98 internally and 0.945 externally, outperforming all growth based metrics, Lung RADS size based triage, European volume and VDT based screening criteria, radiologists, and leading AI models. The model maintains high sensitivity at low false positive rates, excels for small and early stage cancers, and enables malignancy assessment up to one year earlier than radiologists for indeterminate and slow growing nodules. This approach has the potential to streamline lung cancer screening workflows and support earlier, more actionable clinical decision making. |
| title | Beyond Size and Growth: Rethinking Lung Cancer Screening with AI Based Nodule Detection and Diagnosis |
| topic | Computer Vision and Pattern Recognition Neurons and Cognition 92-04 I.2.10; J.6; J.3 |
| url | https://arxiv.org/abs/2512.00281 |