2bNIRS: a portable, multi-distance, broadband oximeter and cytochrome-c-oxidase monitoring system for in vivo applications
Fuente:
arXiv
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Preprint |
| Published: |
2025
|
| Subjects: | |
| Online Access: | |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1866911301991661568 |
|---|---|
| author | Giannoni, Luca Barraclough, Archie Carnati, Chiara Lange, Frederic Tachtsidis, Ilias |
| author_facet | Giannoni, Luca Barraclough, Archie Carnati, Chiara Lange, Frederic Tachtsidis, Ilias |
| contents | Conventional near-infrared spectroscopy (NIRS) instruments typically employ 2-3 wavelengths for monitoring tissue haemodynamics. However, the use of broadband illumination (hundreds of wavelengths) unlocks also the targeting of tissue metabolism by exploiting the wide differential-redox peak of absorption of cytochrome-c-oxidase (CCO). For this purpose, we present here a novel, broadband (780-900nm), multi-distance NIRS system, called 2bNIRS. Compact and portable (20 x 30 x 40 cm3), 2bNIRS was validated using a dynamic, optical phantom con-taining blood and yeast, and benchmarked against a multi-wavelength time-domain NIRS (TD-NIRS) system. Validation confirmed its accuracy in tracking haemody-namic and metabolic changes, with superior oximetry performance achieved via our BRUNO algorithm, which integrates broadband spectral fitting with spatially-re-solved analysis. Preliminary in vivo, human applications demonstrated 2bNIRS ap-plicability to monitoring both muscle tissue, during arm cuff occlusions, and the brain, during frontal cortex activation. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2512_04787 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | 2bNIRS: a portable, multi-distance, broadband oximeter and cytochrome-c-oxidase monitoring system for in vivo applications Giannoni, Luca Barraclough, Archie Carnati, Chiara Lange, Frederic Tachtsidis, Ilias Medical Physics Instrumentation and Detectors Optics Conventional near-infrared spectroscopy (NIRS) instruments typically employ 2-3 wavelengths for monitoring tissue haemodynamics. However, the use of broadband illumination (hundreds of wavelengths) unlocks also the targeting of tissue metabolism by exploiting the wide differential-redox peak of absorption of cytochrome-c-oxidase (CCO). For this purpose, we present here a novel, broadband (780-900nm), multi-distance NIRS system, called 2bNIRS. Compact and portable (20 x 30 x 40 cm3), 2bNIRS was validated using a dynamic, optical phantom con-taining blood and yeast, and benchmarked against a multi-wavelength time-domain NIRS (TD-NIRS) system. Validation confirmed its accuracy in tracking haemody-namic and metabolic changes, with superior oximetry performance achieved via our BRUNO algorithm, which integrates broadband spectral fitting with spatially-re-solved analysis. Preliminary in vivo, human applications demonstrated 2bNIRS ap-plicability to monitoring both muscle tissue, during arm cuff occlusions, and the brain, during frontal cortex activation. |
| title | 2bNIRS: a portable, multi-distance, broadband oximeter and cytochrome-c-oxidase monitoring system for in vivo applications |
| topic | Medical Physics Instrumentation and Detectors Optics |
| url | https://arxiv.org/abs/2512.04787 |