A Functional Approach to Testing Overall Effect of Interaction Between DNA Methylation and SNPs
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arXiv
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| Main Authors: | , , , |
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| Format: | Preprint |
| Published: |
2025
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| _version_ | 1866918307260530688 |
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| author | Gansou, Yvelin Oualkacha, Karim Cremona, Marzia Angela Lakhal-Chaieb, Lajmi |
| author_facet | Gansou, Yvelin Oualkacha, Karim Cremona, Marzia Angela Lakhal-Chaieb, Lajmi |
| contents | We introduce a test for the overall effect of interaction between DNA methylation and a set of single nucleotide polymorphisms (SNPs) on a quantitative phenotype. The developed inference procedure is based on a functional approach that extends existing regression models in functional data analysis. Through extensive simulations, we show that the proposed test effectively controls type I error rates and highlights increased empirical power over existing methods, particularly when multiple interactions are present. The use of the proposed test is illustrated with an application to data from obesity patients and controls. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2512_05276 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | A Functional Approach to Testing Overall Effect of Interaction Between DNA Methylation and SNPs Gansou, Yvelin Oualkacha, Karim Cremona, Marzia Angela Lakhal-Chaieb, Lajmi Methodology Applications We introduce a test for the overall effect of interaction between DNA methylation and a set of single nucleotide polymorphisms (SNPs) on a quantitative phenotype. The developed inference procedure is based on a functional approach that extends existing regression models in functional data analysis. Through extensive simulations, we show that the proposed test effectively controls type I error rates and highlights increased empirical power over existing methods, particularly when multiple interactions are present. The use of the proposed test is illustrated with an application to data from obesity patients and controls. |
| title | A Functional Approach to Testing Overall Effect of Interaction Between DNA Methylation and SNPs |
| topic | Methodology Applications |
| url | https://arxiv.org/abs/2512.05276 |