Fast and Robust Diffusion Posterior Sampling for MR Image Reconstruction Using the Preconditioned Unadjusted Langevin Algorithm

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Main Authors: Blumenthal, Moritz, Holliber, Tina, Tamir, Jonathan I., Uecker, Martin
Format: Preprint
Published: 2025
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author Blumenthal, Moritz
Holliber, Tina
Tamir, Jonathan I.
Uecker, Martin
author_facet Blumenthal, Moritz
Holliber, Tina
Tamir, Jonathan I.
Uecker, Martin
contents Purpose: The Unadjusted Langevin Algorithm (ULA) in combination with diffusion models can generate high quality MRI reconstructions with uncertainty estimation from highly undersampled k-space data. However, sampling methods such as diffusion posterior sampling (DPS) or likelihood annealing suffer from long reconstruction times and the need for parameter tuning. The purpose of this work is to develop a robust sampling algorithm with fast convergence. Theory and Methods: In the reverse diffusion process used for sampling the posterior, the exact likelihood is multiplied with the diffused prior at all noise scales. To overcome the issue of slow convergence, preconditioning is used. The method is trained on fastMRI data and tested on retrospectively undersampled brain data of a healthy volunteer. Results: For posterior sampling in Cartesian and non-Cartesian accelerated MRI the new approach outperforms annealed sampling and DPS in terms of reconstruction speed and sample quality. Conclusion: The proposed exact likelihood with preconditioning enables rapid and reliable posterior sampling across various MRI reconstruction tasks without the need for parameter tuning.
format Preprint
id arxiv_https___arxiv_org_abs_2512_05791
institution arXiv
publishDate 2025
record_format arxiv
spellingShingle Fast and Robust Diffusion Posterior Sampling for MR Image Reconstruction Using the Preconditioned Unadjusted Langevin Algorithm
Blumenthal, Moritz
Holliber, Tina
Tamir, Jonathan I.
Uecker, Martin
Medical Physics
Computer Vision and Pattern Recognition
Machine Learning
Probability
Purpose: The Unadjusted Langevin Algorithm (ULA) in combination with diffusion models can generate high quality MRI reconstructions with uncertainty estimation from highly undersampled k-space data. However, sampling methods such as diffusion posterior sampling (DPS) or likelihood annealing suffer from long reconstruction times and the need for parameter tuning. The purpose of this work is to develop a robust sampling algorithm with fast convergence. Theory and Methods: In the reverse diffusion process used for sampling the posterior, the exact likelihood is multiplied with the diffused prior at all noise scales. To overcome the issue of slow convergence, preconditioning is used. The method is trained on fastMRI data and tested on retrospectively undersampled brain data of a healthy volunteer. Results: For posterior sampling in Cartesian and non-Cartesian accelerated MRI the new approach outperforms annealed sampling and DPS in terms of reconstruction speed and sample quality. Conclusion: The proposed exact likelihood with preconditioning enables rapid and reliable posterior sampling across various MRI reconstruction tasks without the need for parameter tuning.
title Fast and Robust Diffusion Posterior Sampling for MR Image Reconstruction Using the Preconditioned Unadjusted Langevin Algorithm
topic Medical Physics
Computer Vision and Pattern Recognition
Machine Learning
Probability
url https://arxiv.org/abs/2512.05791