Multimodal Oncology Agent for IDH1 Mutation Prediction in Low-Grade Glioma
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arXiv
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| Main Authors: | , , , |
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| Format: | Preprint |
| Published: |
2025
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| _version_ | 1866911304591081472 |
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| author | Akebli, Hafsa Shephard, Adam Della Mea, Vincenzo Rajpoot, Nasir |
| author_facet | Akebli, Hafsa Shephard, Adam Della Mea, Vincenzo Rajpoot, Nasir |
| contents | Low-grade gliomas frequently present IDH1 mutations that define clinically distinct subgroups with specific prognostic and therapeutic implications. This work introduces a Multimodal Oncology Agent (MOA) integrating a histology tool based on the TITAN foundation model for IDH1 mutation prediction in low-grade glioma, combined with reasoning over structured clinical and genomic inputs through PubMed, Google Search, and OncoKB. MOA reports were quantitatively evaluated on 488 patients from the TCGA-LGG cohort against clinical and histology baselines. MOA without the histology tool outperformed the clinical baseline, achieving an F1-score of 0.826 compared to 0.798. When fused with histology features, MOA reached the highest performance with an F1-score of 0.912, exceeding both the histology baseline at 0.894 and the fused histology-clinical baseline at 0.897. These results demonstrate that the proposed agent captures complementary mutation-relevant information enriched through external biomedical sources, enabling accurate IDH1 mutation prediction. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2512_05824 |
| institution | arXiv |
| publishDate | 2025 |
| record_format | arxiv |
| spellingShingle | Multimodal Oncology Agent for IDH1 Mutation Prediction in Low-Grade Glioma Akebli, Hafsa Shephard, Adam Della Mea, Vincenzo Rajpoot, Nasir Artificial Intelligence Computer Vision and Pattern Recognition Low-grade gliomas frequently present IDH1 mutations that define clinically distinct subgroups with specific prognostic and therapeutic implications. This work introduces a Multimodal Oncology Agent (MOA) integrating a histology tool based on the TITAN foundation model for IDH1 mutation prediction in low-grade glioma, combined with reasoning over structured clinical and genomic inputs through PubMed, Google Search, and OncoKB. MOA reports were quantitatively evaluated on 488 patients from the TCGA-LGG cohort against clinical and histology baselines. MOA without the histology tool outperformed the clinical baseline, achieving an F1-score of 0.826 compared to 0.798. When fused with histology features, MOA reached the highest performance with an F1-score of 0.912, exceeding both the histology baseline at 0.894 and the fused histology-clinical baseline at 0.897. These results demonstrate that the proposed agent captures complementary mutation-relevant information enriched through external biomedical sources, enabling accurate IDH1 mutation prediction. |
| title | Multimodal Oncology Agent for IDH1 Mutation Prediction in Low-Grade Glioma |
| topic | Artificial Intelligence Computer Vision and Pattern Recognition |
| url | https://arxiv.org/abs/2512.05824 |